University Of Washington AIDS Clinical Trial Unit: AIDS Ribbon University Of Washington AIDS Clinical Trial Unit Header
UW AIDS Clinical Trial Unit Home Page UW AIDS Clinical Trial Unit Studies UW AIDS Clinical Trial Unit Staff UW AIDS Clinical Trial Unit Links
UW AIDS Clinical Trial Unit Positivemente Latino UW AIDS Clinical Trial Unit Outreach Page UW AIDS Clinical Trial Unit Contact Us Page
University of Washington Seal
5279 FACT SHEET
A Phase III Clinical Trial of Ultra-Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-Infected Individuals with Latent Tuberculosis Infection(ACTG 5279)
Purpose of This Trial:
To compare two treatments to prevent active TB in persons with HIV and latent TB

You may be eligible if you are:
  • HIV positive man or woman, age 18 or older
  • Have a positive Tuberculin skin test ≥ 5mm or a positive interferon gamma release assay(IGRA) at any time prior to study entry
  • No history of treatment for Tuberculosis in last two years
  • No history of multi–drug-resistant or extensively drug resistant (XDR) TB
  • Not on Protease Inhibitor or Raltegravir based anti-retroviral regimen or planning to start one of these regimens within 4 weeks of entry
  • Not pregnant, breast feeding or planning pregnancy (if a woman)
  • Do not have cirrhosis or recent acute hepatitis
Medications While On Study:
Rifapentine, Isoniazid and vitamin B6 (pyridoxine) will be provided while on study. Subjects will take Rifapentine/Isoniazid plus B6 for 4 weeks or Isoniazid plus vitamin B6 for 9 months
Length of Study:
About 4 years (208 weeks)
Schedule of Study Appointments:
Screening, entry, 2, 4, 8, 12, 16, 20, 24, 36, 48, and every 12 weeks starting at week 48
Reimbursement:
Clinical Exams, the Rifapentine, Isoniazid, Vitamin B6 and lab tests are provided at no cost. You will receive $20 per visit starting at Entry.
Contact:
The ACTU Screening Nurse at 206-744-3184.
return to top of page

Home Research Staff Links Latino Outreach Contact Site Map

© University of Washington AIDS Clinical Trial Unit, updated 08/09/2012.