Brockway-M-S. Bannister-J. McClure-J-H. McKeown-D.
Wildsmith-J-A. Comparison of extradural ropivacaine and bupivacaine. Br-J-Anaesth. 1991 Jan. 66(1). P 31-7.
Ropivacaine, a new long acting amide type local anaesthetic,
was compared with bupivacaine in a randomized double-blind
study. One hundred and ten patients undergoing extradural
anaesthesia received a test dose of 3 ml of 1% lignocaine with
adrenaline which was followed by 15 ml of one of five
solutions: 0.5, 0.75 or 1.0% ropivacaine or 0.5 or 0.75%
bupivacaine. There was little difference between the groups
with respect to speed of onset or sensory block. The duration
of analgesia was increased by increasing the concentration of
both drugs, but this had minimal effect on onset time or extent
of block. When the same concentration of each drug was
administered, there were inconsistent differences in duration of sensory block, none of which was statistically significant.
Increasing concentration of both drugs resulted in greater
degree and longer duration of motor block. Ropivacaine produced
a slower onset, shorter duration and less intense motor block
than the same concentration of bupivacaine. The cardiovascular
changes were similar in all groups.