Pharmacokinetic parameters describing the disposition of bupivacaine and ropivacaine.
3
Parameter
Bupivacaine
Ropivacaine
t1/2 (min)
162
111
Cl (L/min)
0.58
0.73
Vss(L)
73
59
protein binding (%)
96
94
pKa
8.0
8.1