Anesthesiology & Pain Medicine >> Research >> Focus Areas >> Outcomes >> Abdominal Symptom Phenotypes: Pathways to New Biomarkers
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Research Focus Areas:

Abdominal Symptom Phenotypes: Pathways to New Biomarkers

Principal Investigators

M. M. Heitkemper, Ph.D., R. Shulman, M.D., P. G. Richebé, M.D, Ph.D., et al.


This application is responsive to NINR priorities related to discovery of biomarkers and understanding linkages between symptoms and biomarkers, the mechanisms leading to symptoms, and ultimately symptom management. Functional gastrointestinal (GI) disorders (FGIDs), in particular irritable bowel syndrome (IBS) in adults and children, are among the most common and costly health care problems in the US. In adults, IBS disproportionately affects women (10-15% of women in western nations) and adolescent girls. There are well-recognized associations between IBS and other conditions (fibromyalgia, headache) and symptoms (depression, fatigue, insomnia). Therapies are typically prescribed to relieve particular symptoms (drugs such as antispasmodics, analgesics or antidepressants for pain, laxatives, antidiarrheals) or change lifestyle features (e.g., diet, cognitive behavioral therapy, hypnosis, or comprehensive self management2, 3 to modify coping ability). We posit that by understanding better these different expressions of IBS (i.e., better defined patient subgroups) and linking them to newer biomarkers, ultimately greater progress on understanding the etiologies and defining effective treatments can be achieved. Our Specific Aims are to 1) use existing symptom diary data on 400 women with IBS from two studies to define clusters of women with differing symptoms. A similar approach will be taken using diary data from 100 girls with IBS. 2) Perform proteomic analyses of urine samples from the women and girls in Aim 1 and identify potential biomarkers, namely proteins whose levels differ between IBS and Control groups. 3) Advances in high throughput genomics and proteomics have increased the potential for new biomarkers including urine proteomics. We will recruit 20 women and 20 girls with IBS and 40 Controls (20 women, 20 girls). Collect diary data, urine samples for proteomics, serum for lymphocyte activation, cytokine expression and perform DNIC and video capsule endoscopy procedures. The goals of this application will be accomplished by developing infrastructure (equipment and collaborations), partnerships with industry and resources necessary to collect preliminary data for larger mechanistic and intervention studies.

Research Projects

A Nursing Study of Gut Function in Menstruating Women
M. M. Heitkemper, Ph.D., M. E. Jarrett, Ph.D., P. G. Richebé, M.D., Ph.D.
Abdominal Symptom Phenotypes: Pathways to New Biomarkers
M. M. Heitkemper, Ph.D., R. Shulman, M.D., P. G. Richebé, M.D, Ph.D., et al.
Closed Claims Project
K. Domino, M.D., MPH, K. Posner, Ph.D., F.W. Cheney, M.D., L. Lee, M.D.
Computerized Glucose Control in Critically Ill Patients
M. Horibe, M.D., J.D. Lang, M.D., B. G. Nair, Ph.D.
Determination of Risk Factors for Ischemic Optic Neuropathy After Spine Surgery
Lorri A. Lee, M.D.K., Domino, MD,MPH, K. Posner, PhD, et al.
Extubation Failure in Patients with Difficult Airways Study
M. M. Treggiari, M.D., Ph.D., M.P.H.
lst Tier Drugs + Theophylline In Pediatric Severe Asthma
J. Zimmerman, M.D., D. Jardine, M.D.
Pharmacokinetics of Intrathecal Drug Infusions
C.M. Bernards, MD, S. Flack, MBChB
Real-Time Electronic Alerts to Improve Antibiotic and Temperature Management in Surgical Patients
B. G. Nair, Ph.D., H. A. Schwid, M.D.
Resource Over Utilization due to Serious Alcohol Related Injuries (CR)
J. Jarvik, M.D., M.P.H., B.S. Roudsari, Ph.D., M.S. Vavilala, M.D., B. Bresnahan, Ph.D
SIDS and the Inner Ear: A Follow up study of Hearing, Vestibular Function and Respiratory Control
D. Rubens, M.D.
The Association Between Innate Immunity Genes and Outcome Following Sepsis in Children
J. H. Kim, M.D., G. P. Jarvik, M.D., D. Jardine, M.D.
The Gas Study: Comparing Neurodevelopment Outcome and Apnea in Infants
M.E, McCann, M.D., A. Lynn, M.D.
The Influence of Inhaled Nitric Oxide on Attenuating Hepatic Sinusoidal Leukocyte-Endothelial Interactions in Patients Undergoing Orthopic Liver Transplantation
J.D. Lang, Jr, M.D.
Use of Transthoracic Ultrasound to Triage Patients in Preanesthesia Clinic
E. Wako, M.D., G. Van Norman, M.D., G.A. Rooke, MD., Ph.D.