Anesthesiology & Pain Medicine >> Research >> Focus Areas >> Outcomes >> Determination of Risk Factors for Ischemic Optic Neuropathy After Spine Surgery
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Research Focus Areas:

Determination of Risk Factors for Ischemic Optic Neuropathy After Spine Surgery

Principal Investigators

Lorri A. Lee, M.D.K., Domino, MD,MPH, K. Posner, PhD, et al.


One of the most devastating iatrogenic complications that can occur perioperatively is postoperative visual loss (POVL). Data from the American Society of Anesthesiologists (ASA) POVL Registry has provided important information on the perioperative characteristics of patients who developed ischemic optic neuropathy (ION) after spine surgery. However, it is unclear from these data if co-existing diseases, gender, hematocrit, blood pressure management, and other factors increase the risk of developing ION because there are no denominator data. We therefore propose to evaluate potential risk factors for ION after spine surgery using a multi-center randomized case control study in which patients with ION from the ASA POVL Registry (n = 80) will be compared to matched controls who did not develop ION after spine surgery. Determination of risk factors for perioperative ION after spine surgery could potentially identify 1) high risk pre-existing patient characteristics; and 2) perioperative events that may increase the risk of ION such as blood pressure management, type of fluid replacement, blood transfusion / hematocrit management, anesthesia / prone duration, or and use of vasopressors. These data could also be used to determine the odds ratio for developing ION for every additional hour of anesthesia and every liter of blood loss. These results could be used by both spine surgeons and anesthesiologists to improve patient safety by influencing appropriate patient selection and perioperative anesthetic and surgical management of prolonged spine operations with the goal of reducing the incidence of this devastating complication. Pharmacokinetics of Intrathecal Drug Infusions.

Research Projects

A Nursing Study of Gut Function in Menstruating Women
M. M. Heitkemper, Ph.D., M. E. Jarrett, Ph.D., P. G. Richebé, M.D., Ph.D.
Abdominal Symptom Phenotypes: Pathways to New Biomarkers
M. M. Heitkemper, Ph.D., R. Shulman, M.D., P. G. Richebé, M.D, Ph.D., et al.
Closed Claims Project
K. Domino, M.D., MPH, K. Posner, Ph.D., F.W. Cheney, M.D., L. Lee, M.D.
Computerized Glucose Control in Critically Ill Patients
M. Horibe, M.D., J.D. Lang, M.D., B. G. Nair, Ph.D.
Determination of Risk Factors for Ischemic Optic Neuropathy After Spine Surgery
Lorri A. Lee, M.D.K., Domino, MD,MPH, K. Posner, PhD, et al.
Extubation Failure in Patients with Difficult Airways Study
M. M. Treggiari, M.D., Ph.D., M.P.H.
lst Tier Drugs + Theophylline In Pediatric Severe Asthma
J. Zimmerman, M.D., D. Jardine, M.D.
Pharmacokinetics of Intrathecal Drug Infusions
C.M. Bernards, MD, S. Flack, MBChB
Real-Time Electronic Alerts to Improve Antibiotic and Temperature Management in Surgical Patients
B. G. Nair, Ph.D., H. A. Schwid, M.D.
Resource Over Utilization due to Serious Alcohol Related Injuries (CR)
J. Jarvik, M.D., M.P.H., B.S. Roudsari, Ph.D., M.S. Vavilala, M.D., B. Bresnahan, Ph.D
SIDS and the Inner Ear: A Follow up study of Hearing, Vestibular Function and Respiratory Control
D. Rubens, M.D.
The Association Between Innate Immunity Genes and Outcome Following Sepsis in Children
J. H. Kim, M.D., G. P. Jarvik, M.D., D. Jardine, M.D.
The Gas Study: Comparing Neurodevelopment Outcome and Apnea in Infants
M.E, McCann, M.D., A. Lynn, M.D.
The Influence of Inhaled Nitric Oxide on Attenuating Hepatic Sinusoidal Leukocyte-Endothelial Interactions in Patients Undergoing Orthopic Liver Transplantation
J.D. Lang, Jr, M.D.
Use of Transthoracic Ultrasound to Triage Patients in Preanesthesia Clinic
E. Wako, M.D., G. Van Norman, M.D., G.A. Rooke, MD., Ph.D.