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Mark R. Opp, PhD
Opp Laboratory
Mark R. Opp, PhD
- Professor & Vice Chair for Basic Research, Department of Anesthesiology and Pain Medicine
- UW Medicine Research & Education Endowed Chair in Anesthesiology
Research
- To determine the mechanisms and functional consequences of infection-induced alterations in sleep.
Honors and Awards
- 2005—2007 President-Elect, President, Past-President, Sleep Research Society
- 2007—2008 President, Associated Professional Sleep Societies
- 2006 American Academy of Sleep Medicine/Pfizer Visiting Professorship in Sleep Medicine, Baylor College of Medicine
- 2007—2008 President, Associated Professional Sleep Societies
Current Memberships
- 1992—American Academy of Sleep Medicine
- 1986—American Physiological Society
- 1985—European Sleep Research Society
- 1989—Sleep Research Society
- 1996—Society for Neuroscience
- 2005—PsychoNeuroImmunology Research Society
Current Funding
- 08/25/08—07/24/13 National Institutes of Health, 5R01MH064843,
"Cytokine And Neurotransmitter Interactions in Sleep Regulation" - 07/01/12—06/30/17 National Institutes of Health, 2R01HD036520,
"Molecular Mechanisms of Sleep Responses to Viral Infection" - 04/15/11—02/28/16 National Institutes of Health, 5R01NR012294,
"Neonatal Pain, Depression and Pain Susceptibility at Maturity in Rats" - 09/30/12—08/31/17 National Institutes of Health, 1R01AG041287,
"Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain Barrier"
Selected Publications
- Morrow JD, Vikraman S, Imeri L, Opp MR. Effects of serotonergic activation by 5-hydroxytryptophan on sleep and body temperature of C57BL/6J and interleukin-6-deficient mice are dose and time-related. SLEEP 31: 21-33, 2008.
- Olivadoti MD, Opp MR. Effects of intracerebroventricular administration of interleukin (IL)-1 on sleep and body temperature of IL-6-deficient mice. Neuroscience 153: 338-348, 2008.
- Nemzek JA, Hugunin KM, Opp MR. Modeling sepsis in the laboratory: merging sound science with animal well-being. Comp. Med. 58: 1-9, 2008.
- Baracchi F, Opp MR. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain, Behav. Immunity 22: 982-993, 2008.
- Datta SC, Opp MR. Lipopolysaccharide-induced alterations in multiple cytokines detected in discrete mouse brain regions using Luminex xMAP® technology. J. Neurosci. Methods 175: 119-124, 2008.
- Opp MR. Sleeping to fuel the immune system: mammalian sleep and resistance to parasites. BMC Evolutionary Biology 9:8, 2009.
- Imeri L, Opp MR. How (and why) the immune system makes us sleep. Nat Rev Neurosci. 10: 199-210, 2009.
- Brambilla D, Barajon I, Bianchi S, Opp MR, Imeri L. Interleukin-1 inhibits putative cholinergic neurons in vitro and rapid eye movement sleep when microinjected into the rat laterodorsal tegmental nucleus. SLEEP 33: 919-929, 2010.
- Olivadoti MD, Weinberg JB, Toth LA, Opp MR. Sleep and fatigue in mice infected with murine gammaherpesvirus 68. Brain, Behav. Immunity 25: 696-705, 2011.
- Baracchi F, Ingiosi AM, Raymond RM Jr, Opp MR. Sepsis-induced alterations in sleep of rats. Am. J. Physiol. 301: R1467-R1478, 2011.