Anesthesiology & Pain Medicine >> Research >> Labs >> Tian Lab
Photo of Rong Tian, MD, PhD
Rong Tian, MD, PhD

Tian Laboratory
Rong Tian, MD, PhD

  • Director, Mitochondria and Metabolism Center
  • Co-director, NMR center
  • Professor, Anesthesiology and Pain Medicine, Bioengineering
  • Adjunct Professor, Biochemistry

Research

  • Energy metabolism in cardiovascular diseases
  • Mitochondrial dysfunction and metabolic signaling
  • NMR spectroscopy and Imaging-guided spectroscopy

Selected Publications

  • Karamanlidis G, Lee CF, Garcia-Menendez L, Kolwicz Jr. SC, Suthammarak W, Gong G, Sedensky MM, Morgan PG, Wang W, Tian R. Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metabolism. 2013 Aug 6;18(2):239-250.
  • Kolwicz Jr. SC, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R. Cardiac-specific deletion of acetyl CoA carboxylase 2 (ACC2) prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res 2012, Aug 31; 111(6): 728-38. PMID: 22730442
  • Karamanlidis G, Nascimben L, Couper GS, Shekar PS, Tian R. Defective DNA replication impairs mitochondrial biogenesis In human failing hearts. Circ Res. 2010.
  • Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R. Increased glucose uptake and oxidation in mouse hearts prevents high fatty acid oxidation but causes cardiac dysfunction in diet-induced obesity. Circulation 2009; 119:2818-2828.
  • Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M , Seidman CE, Seidman JG, Ingwall JS ,Balschi JA, and Tian R. Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest. 2007; 117(5):1432-9.