Heparin Infusion Guidelines

UWMedicine Standard Protocols – Initiation Dosing

1. Order standard heparin infusion with starting rate defaulted based on indication

2. Order Loading Bolus, if warranted

3. Order Goal PTT (Regular intensity: 60-100 seconds; Low intensity: 60-80 seconds)

4. Order PRN rebolus for subtherapeutic PTT, if warranted

INDICATION

LOADING BOLUS

(maximum 10,000 units)

INITIAL INFUSION RATE

PRN RE-BOLUS FOR LOW PTT

(maximum 5000 units)

FIRST PTT CHECK

Acute Thrombosis Treatment

(eg: DVT/PE)

80 units/kg 18 units/kg/hr

PTT 50-59:

25 units/kg

 

PTT < 50:

50 units/kg

6 hours after starting infusion
Atrial Fibrillation, Valve Replacement, Peri-operative Bridging, Other 70 units/kg 15 units/kg/hr
Acute Coronary Syndrome 50 units/kg 12 units/kg/hr
Acute Ischemic Stroke none 12 units/kg/hr