General dosing guidelines

Please see the attached document for dosing guidelines for LMWHs at UW Medicine.

NOTE:  anectodal clinical and pharmacokinetic evidence at UW Medicine dating back to the early 1990s suggests that the clearance of enoxaparin is compromised in the presence of the calcineurin inhibitors (CNI) cyclosporine and tacrolimus.  It is our practice to reduce full dose enoxaparin by one level (from 1mg/kg SQ q12h to 0.85mg/kg SQ q12h, or from 0.85mg/kg SQ q12h to 1mg/kg SQ q24h) in patients on concurrent CNI therapy.