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Vol. III, No. 11 ~ EINet News Briefs ~ August 24, 2000


****A free service of the APEC Emerging Infections Network*****

The EINet listserv was created to foster discussion, networking, and collaboration in the area of emerging infectious diseases (EID's) among academicians, scientists, and policy makers in the Asia–Pacific region. We strongly encourage you to share their perspectives and experiences, as your participation directly contributes to the richness of the "electronic discussions" that occur. To respond to the listserv, use the reply function.


In this edition:

  1. Infectious disease information from ProMED and other sources
  2. Updates from previous bulletins
  3. Notices
  4. How to join the EINet listserv


1. OVERVIEW OF INFECTIOUS–DISEASE INFORMATION FROM PROMED  
Below is a bi–weekly summary of Asia–Pacific EID issues based on postings to the ProMED Electronic Network and other sources. ProMED is the prototype for a communications system that monitors emerging infectious diseases globally, an initiative of the Federation of American Scientists (FAS), and co–sponsored by WHO.

ASIA

ENTEROVIRUS 71 FATALITY
The Department of Health has confirmed the death of a 5–year old girl who was infected with enterovirus 71 (EV71) during a trip to China. Health officials believe this is a sporadic and imported case. This is the 2nd fatal case recorded since the government established the surveillance program during the outbreaks in 1998.

EV71 is associated with severe forms of hand foot and mouth disease. Infection usually causes mild symptoms; however, death can also result. Last year, 22 cases were confirmed.
[SOUTH CHINA MORNING POST 8/18/00]

VIETNAM––SUCCESS AGAINST POLIO
According to the National Committee for Certification of Polio Eradication (NCCPE), Vietnam has met World Health Organization (WHO) standards on total polio eradication. This accomplishment has been attributed to the 1996 implementation of the Expanded Immunization Program (EPI), which includes a highly effective polio supervision system. International recognition of Vietnam's polio–free status is expected in October.

Vietnam's strategy to remain polio–free with involve the vaccination of over 90% of children 1> year (each child will receive 3 doses of oral polio vaccine (OPV)). At least 3 million doses of OPV will be available to children should the disease reappear. No cases of polio have been contracted in the country since February 1997.
[VNN 8/10/00]

HEALTH MINISTERS MEET ON HEALTHCARE FOR POOR
Health ministers from Southeast Asia will meet in Nepal to discuss health sector reforms, the AIDS epidemic, and methods to provide inexpensive healthcare to the poor. Other issues will encompass the impact of poverty, illiteracy, the emergence of new diseases like HIV, and the reemergence of tuberculosis (TB) and malaria, on the region's medical infrastructure.
[SEA–AIDS 8/24/00]


OCEANIA

NEW ZEALAND––FOODBORNE ILLNESSES
Foodborne illnesses account for $NZ55 million in costs each year ($462/case). These costs include $48.1 million in lost productivity, $2.1 million for transport, $200,000 in direct non–medical costs, $4.7 million for the intangible costs associated with death, and almost 800,000 productive days from foodborne associated illnesses.

Infectious intestinal diseases cost the economy an estimated $216 million annually. Campylobacter, which is found in a wide range of poultry and meats, accounts for 63% of all foodborne illnesses reported.
[NEW ZEALAND HERALD 7/17/00]


AMERICAS


USA (WISCONSIN)––E.COLI OUTBREAK
Milwaukee health officials have registered 42 E.Coli cases, including 1 fatality in a 3 year–old girl. To date, a total of 18 adults and 24 children (aged 1 to 15) have been affected. The outbreak has been traced to the Sizzler Steakhouse Restaurant in Milwaukee during July 10 and July 26; the restaurant has been closed temporarily.

This is the largest E.Coli outbreak ever recorded in Milwaukee.
[REUTERS 8/1/00 & 7/31/00]

USA(TEXAS)––INFLUENZA OUTBREAK
Health officials have confirmed 2 flu cases, and continue to investigate at least 65 additional cases at a children's camp south of Waco. The ill children have been isolated to one area of the camp. The source of the outbreak is yet to be determined. The camp has over 400 campers (aged 9 to 16 years) and more than 150 staffers.

This is the season's first outbreak. Influenza is traditionally a winter illness that can begin as early as October and last until spring. Recently, the CDC announced that the season's vaccine will be delivered late, and that the shot will not be available until November. Approximately 20,000 fatal cases are reported annually in the U.S.
[FORT WORTH STAR TELEGRAM 7/21/00]

USA (CALIFORNIA)––ARENAVIRUS LINKED TO DEATHS
Health officials have linked 3 deaths to arenavirus, an often fatal respiratory rodent–borne disease. The cases were all females, aged 14, 30, and 52. Onset of illness was reported between June 1999 and May 2000; the patients did not participate in any common activities. None of the cases reported travel outside of California prior to illness. Only 1 patient had a history of rodent contact.

Human transmission of disease occurs through the inhalation of dust contaminated with urine, feces, or saliva of infected rodents. The virus has almost never before infected humans in North America; variations of the virus have been seen among overseas travelers and laboratory workers accidentally exposed during research. The public has been advised to avoid contact with wild rodents or any wild animals, to properly dispose of trash, to avoid camping near rodent droppings, burrows, nests, and to avoid treating dust when cleaning rodent–infested areas by first wetting the areas with bleach.
[MMWR 8/11/00; REUTERS 8/3/00]


OTHER

RUSSIA (ST.PETERSBURG)––INFECTIOUS DISEASE RATES
Health officials have reported a 20% decline of infectious disease cases, and over a 50% decrease of fatalities associated with these diseases during the first 7 months of this year, relative to the same time period last year.

Conversely, the Health Commission has reported the largest rise of HIV cases in 5 years, and a 90% tuberculosis (TB) rate in the city's population. The increase of these diseases has been attributed to the influx of refugees from zones in the former Soviet Central Asian republics and soldiers returning from 'hot spots' in the former republics. Other contributing factors include unsanitary conditions, declining social standards, and the absence of a vaccination program.
[ST PETERSBURG TIMES 8/14/00]

TYPHUS MAY FIGHT HIV
According to the joint US–Thai Funded Armed Forces Institute of Medical Sciences, the tropical disease typhus can suppress HIV to undetectable levels. The study revealed a significant drop in virus count among AIDS patients after a case of scrub typhus, a potentially fatal mosquito–borne disease. Scrub typhus is common in east Asia and the west Pacific.

Plasma was obtained from scrub typhus patients not infected with HIV and transferred to HIV patients; subsequently, HIV viral load decreased substantially. Scientists believe that this discovery will contribute to the development of an inexpensive HIV–AIDS treatment.

Currently, over 30 million people are infected with HIV or full–blown AIDS; the majority of these cases cannot afford the expensive combination drug "cocktail" treatments that are readily available in more industrialized countries. At least 1 million people are infected in Thailand; however, less than 10% of these cases can afford the modern drug cocktail treatments.
[BBC NEWS 8/9/00; STRAITS TIME INTERACTIVE 8/9/00; YAHOO NEWS SINGAPORE 8/8/00]

TREATMENT OF SEXUALLY TRANSMITTED DISEASES HELPS REDUCE HIV TRANSMISSION
An analysis conducted by the Ad Hoc STD/HIV Transmission Group revealed a 27% reduction of HIV transmission with treatment of sexually transmitted diseases (STD). The data was collected on HIV positive attendees of STD clinics at 8 sites in the U.S.; each site submitted between 1 to 2 years of data from early– to mid– 1990s. The proportion that was dually infected ranged from 14% to 67.5%. The proportion of cases prevented by intervention was approximately 0.8.

Investigators referred to previous literature reports to indicate a relative risk of 3 for increased HIV transmission among co–infected persons compared to those who were not infected with a STD. Literature–based transmission probabilities were used to calculate the number of cases that would be prevented among HIV infected patients with STD treatment; the estimates revealed a 10㪾% decline of potential HIV transmission.
[SEXUAL TRANSMISSION DISEASE 2000; 27: 411ע]


2. UPDATES FROM PREVIOUS BULLETINS

MALAYSIA––NIPAH VIRUS
Researchers at the Department of Microbiology, University of Malaya, have confirmed a link between fruit bats and Nipah virus, after strains of the virus were isolated in island flying foxes, a species of fruit bats that live throughout Southeast Asia. The discovery proves that bats are carriers or reservoirs of the virus.

Last year, the virus––which crossed over to pigs and then to humans––caused over 100 fatalities. Antibodies against Nipah have also been found in other species of fruit bats. The virus has also been known to infect dogs, cats, and horses. The U.S Centers for Disease Control and Prevention (CDC) recently added Nipah Virus to the same class of viruses as Ebola and AIDS.
[NY TIMES 8/15/00]

JAPAN––CONTAMINATED MILK
Health officials have conducted on–the–spot inspection of Snow Brand Milk Products after a toxin was discovered in its powdered skim milk late last month. Contamination was found in 2 samples (n=25) of powdered skim milk; each gram had approximately 4 nanograms of enterotoxin, an adequate amount to cause food poisoning.

Snow Brand Milk Products intends to reinspect all powdered skim milk products at factories nationwide.
[MAINICHI DAILY NEWS 8/20/00]

NEW ZEALAND––MENINGOCOCCAL DISEASE LINKED TO CROWDED HOMES According to a 3–year study looking at risk factors of meningococcal disease, household crowding has contributed significantly to the nation's decade long epidemic. Researchers indicated a 50% increased risk of disease among children living in overcrowded conditions. In response to this finding, the government has agreed to help improve living conditions by increasing the stock of state houses and introducing income–related rents.

The current national average of disease is 14.8 cases per 100,000 people.
[NEW ZEALAND HERALD 8/15/00; MAUKAU COURIER 8/15/00]


3. NOTICES IMMUNIZATION ONLINE PUBLICATION
The Global Alliance for Vaccines and Immunization (GAVI) has launched "Immunization Focus", a quarterly online publication of updates and debates about immunization issues at national and international levels. Departments include news, special features, conference reports, and grassroot views. GAVI is a partnership of public and private organizations dedicated to increasing access to immunization among children worldwide.

GAVI members include the Bill and Melinda Gates Children's Vaccine Program, International Federation of Pharmaceuticals Manufacturers Association (IFPMA), public health and research institutions, national governments, Rockefeller Foundation, UNICEF, World Bank, and World Health Organization.
[www.vaccinealliance.org 8/2/00]


4. JOIN THE E–LIST AND RECEIVE EINet NEWS BRIEFS REGULARLY
The APEC EINet listserv was established to enhance collaboration among academicians and public health professionals in the area of emerging infections surveillance and control. Subscribers are encouraged to share their material with colleagues in the Asia–Pacific Rim. To subscribe (or unsubscribe), please contact nwc@u.washington.edu. Further information about the APEC Emerging Infections Network is available at http://www.apec.org/infectious.

Revised:
April 21, 1999

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