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About EINet
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Vol. VI, No. 10~ EINet News Briefs ~ June 6 , 2003
****A free service of the APEC Emerging Infections Network*****
The EINet list serve was created to foster discussion, networking, and collaboration in the area of emerging infectious diseases (EID's) among academicians, scientists, and policy makers in the AsiaPacific region. We strongly encourage you to share your perspectives and experiences, as your participation directly contributes to the richness of the "electronic discussions" that occur. To respond to the list serve, use the reply function. In this edition:
1. OVERVIEW OF INFECTIOUSDISEASE INFORMATION Below is a semimonthly summary of AsiaPacific emerging infectious diseases. ASIA Vietnam 7 Children Die from Suspected Japanese Encephalitis
Seven children have died from suspected Japanese encephalitis in northern Vietnam since early April 2003. The children, all under the age of 5 years, died within 48 hours of being brought to the Central Paediatric Hospital in Hanoi from other hospitals in northern provinces, according to a doctor there. "One child died today, and currently we have 115 other children from around 10 northern provinces in our hospital with similar symptoms," he said on May 22, 2003. "The children who died all experienced high fever and convulsions before falling into a coma and passing away," the doctor said. "We suspect they had contracted Japanese encephalitis." Japanese encephalitis is a viral disease spread by infected mosquitoes in agricultural regions of Asia. It was first detected in Vietnam in 1985. It is one of several mosquitoborne viruses that can affect the central nervous system and cause severe complications and death. There is no cure for the disease. Fatality rates are about 20 percent in children and more than 50 percent in adults. Japanese encephalitis is endemic in parts of Vietnam; pigs are the reservoir.
Human and livestock vaccines are available. New Zealand — Paralytic shellfish poisoning Some marae may have hosted functions over the weekend and could have collected shellfish earlier, holding it in storage. It is the second time since April 2003 that a ban has been placed on Bay of Islands shellfish. The toxin, which can cause paralysis and death, was attributed to a PSPproducing phytoplankton. The first warning was lifted on 2 May, 2003. Health officials believed the latest PSP levels were probably due to the toxic algae Alexandrium tamarense. Signs and symptoms of poisoning include numbness and tingling around the mouth, face, or extremities; difficulty swallowing and breathing; dizziness; double vision and paralysis. Kina, mussels, toheroa, pipi, tuatua, oysters, and cockles in affected areas
should not be eaten. Paua, crab, and crayfish may still be eaten if the gut
has been completely removed prior to cooking. Fish, such as snapper, gurnard,
and terakihi are not affected by the algae and are still safe to eat. Russia (Southwest Siberia) – New Rabies Virus Found
in Bats In 2002, researchers caught 18 bats (species Myotis daubentonii) in caves in the Novosibirsk region of southwest Siberia. Applying fluorescent antibody microscopy analysis, they determined that 6 samples were positive for rabies virus. The serological data were followed by detecting the rabies antigen in the samples by RTPCR analysis. By comparing their isolates of rabies virus with known rabies virus sequences available in the Gene Bank, it appears that in the bats caught in the Novosibirsk region, the circulating rabies virus is the classical genotype 1. Closest to it on the viral genealogical tree is fixed strain CVS, a rabies virus isolated in France, Japan, and Brazil. Next closest are other animals and rabies virus isolates from bats in the
USA. They have found that classical rabies virus in bats circulates in
our region of southwest Siberia. This is the closest rabies viral variant
to
the rabies virus isolated previously in bats in the USA. AMERICAS
A Franklin County man became ill in midMay, 2003, and is being evaluated for suspected West Nile virus (WNV) infection. He was treated as an outpatient and is now recovering. Preliminary tests by CDC have identified St. Louis encephalitis. If confirmed, this would be the first identified case of it in Washington State since 1972. St. Louis encephalitis virus has many similarities to West Nile virus. The illness is not spread person to person; it is transmitted by mosquitoes that become infected by feeding on infected birds. People cannot get the infection directly from birds or other animals. "These new test results don’t change our recommendations about mosquito bite prevention," said state Health Officer Dr. Maxine Hayes. "Much like West Nile virus, St. Louis encephalitis is spread by mosquitoes. The best way to avoid these illnesses is to take steps to prevent being bitten and reduce mosquito habitat around your home." Infection with St. Louis encephalitis virus has symptoms similar to those caused by West Nile virus. Mild infections often go undiagnosed; symptoms include fever and headache. More severe infections have symptoms that include headache, high fever, neck stiffness, and disorientation. There is no treatment or vaccine available for St. Louis encephalitis. People who become ill are treated with supportive care. "State and local health departments have been working closely with health care providers to make sure they are on the look out for West Nile virus," said Dr. Jo Hofmann, State Epidemiologist for Communicable Disease for the Washington State Department of Health. "Because the symptoms are similar, it is possible increased surveillance will result in more cases of encephalitis caused by other viruses being identified as well." According to the CDC, there were 4,478 confirmed cases of St. Louis encephalitis in the United States between 1964 and 1998. Only three of those cases were in Washington state — the last in 1972. The most recent outbreak nationally was in New Orleans, Louisiana in 1999, with 20 reported cases. "Just because it looks like this is not a West Nile virus case, we can’t
let our guard down," said BentonFranklin Health Officer Dr. Larry Jecha. "Last
year our state had positive West Nile cases in birds and horses, and we expect
to see human cases this summer. Besides, protecting yourself from mosquito
bites will limit your chances of being infected with West Nile virus or St.
Louis encephalitis." USA (Montana) — Fourth Case of Hantavirus Infection in Month
of May This hantavirus case is Montana's fourth in the past month and the first ever in Toole County, health officials said. It is the 21st case of the disease in Montana since it first appeared in the state in 1993. 5 Montanans have died from the disease, including a 27yearold man from Lewis and Clark County who died last week in Helena. A 26yearold Cascade County woman died of hantavirus on May 8, 2003, and a Dillon man in his 60s tested positive for the virus a week later. He was released from a Dillon hospital and was expected to recover. Health officials have said most cases of the virus come from prolonged exposure
to rodents in a home or workplace. The best way to prevent the disease is to
make sure to keep mice out of your house and to take precautions when cleaning
out places that might have harbored mice, such as old barns or sheds. Multi Country Outbreak — Severe Acute Respiratory Syndrome (SARS) Status of diagnostic tests The low sensitivity of current virus detection tests is a particular challenge for SARS control, as patients are capable of infecting others during the initial phase and therefore need to be reliably detected and quickly isolated. In SARS patients, detectable immune responses do not begin until day 5 or 6. Reliable antibody tests can detect virus only by around day 10 following the onset of symptoms. WHO continues to recommend use of its case definitions, based on clinical presentation, distinct chest Xrays, and history of possible contact with SARS patients, to detect suspect and probable cases and make management decisions. Training course in China Speculation of origin Dr. Henry Niman, Instructor in Surgery (Bioengineering), Harvard Medical School, mentioned in ProMEDmail that “it seems highly unlikely that the civet cat coronavirus was due to human infection of civets or any other animal (as no SARS coronavirus has been detected with a 29nucleotide insertion which would restore homology to the carboxyl portion of the spike protein).” Please see more details at the following URL: Cumulative cases In order to see further details, including cumulative number of cases and
deaths, please visit the following URL: For the full WHO travel advisory, together with additional information about
this disease, please visit the following URL: For information from CDC including guidelines and recommendations, please
visit the following URL: For information from Department of Health Hong Kong SAR, please visit the
following URL: For information from Singapore Ministry of Health, please visit the following
URL: WHO Global Conference on Severe Acute Respiratory Syndrome
(SARS): “Where
do we go from here?” Public health practitioners and leading experts on SARS have been
invited. An additional 400 places will be provided to others interested
in attending the meeting. For these places, registration is required
prior to the meeting; places will be given to the first 400 registration
forms received. There is no registration fee.
For more details, please visit the following WHO website: NIH and Gates Foundation issue call for ideas on global health challenges The Bill & Melinda Gates Foundation committed $200 million to
establish the Grand Challenges in Global Health initiative, in partnership
with the National Institutes of Health (NIH) and the Foundation for
the National Institutes of Health (FNIH). Dr. Varmus serves as scientific
board chairman of the Grand Challenges in Global Health initiative.
The goal of the initiative is to identify critical scientific and/or
technical challenges, which, if solved, could lead to important advances
against diseases and improve health in the developing world.
Before June 15, health researchers around the world are encouraged
to submit their ideas on what they consider to be the scientific challenges
in global health at this time. Ten to 15 of the most compelling challenges
will be selected from the submissions received. The resulting "Grand
Challenges" will be announced this fall, and solicitations for
research grant proposals to address them will follow.
Information: http://www.grandchallengesgh.org
The annual ASHM conference is the major forum for the presentation
of HIV and hepatitis research in Australasia and you will hear about
all the latest advances from leading local and international figures
such as Carol Jenkins, Alan Landay, Martin Markowitz, Haikin Rachmat,
Ninkama Moiya, Greg Dore, Graham Cooksley, Dennis Altman and Zubairi
Djoerban.
A wide range of plenary, symposium, workshop and concurrent sessions
are planned to cover the fields of Aboriginal & Torres Strait Islander
Health, Basic Science, Clinical Management, Epidemiology, Hepatitis,
International & Regional Issues, Medical Education and Technology, ABSTRACT SUBMISSION: For further information or to register online visit the following
URL: Smoking among Indonesian celebrities – Final result “The results are as follows:
4. JOIN THE ELIST AND RECEIVE EINet NEWS BRIEFS REGULARLY The APEC EINet listserv was established to enhance collaboration among academicians and public health professionals in the area of emerging infections surveillance and control. Subscribers are encouraged to share their material with colleagues in the AsiaPacific Rim. To subscribe (or unsubscribe), contact apecein@u.washington.edu. Further information about the APEC Emerging Infections Network is available at http://www.apec.org/infectious. |
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