Jeremy Mills

My interest in scientific research began as a summer student in the laboratory of Professor David Niesel at the University of Texas Medical Branch in Galveston, Texas, where I studied phosphate uptake in S. pneumoniae. I then carried out undergraduate research in the laboratory of Professor Ned Porter at Vanderbilt University where my research focused on the study of free radical reactions of biological importance.  My graduate studies were conducted in the laboratory of Professor Pete Schultz at The Scripps Research Institute in La Jolla, California. At Scripps, my main research focuses involved using traditional methods of directed evolution in concert with unnatural amino acid technologies to engineer novel functions in antibody frameworks. In 2010, I began postdoctoral studies in the Baker lab where my research centers on combining computational protein design methods with unnatural amino acids to generate designed proteins in which the non-canonical amino acids contribute to protein function.

While in the Baker lab, I have also enjoyed serving as an advisor for the UW iGEM team from 2010-2013. iGEM is a yearly competition in which undergraduates from across the globe conduct research in the broad field of synthetic biology during the summer, and present their research each fall at M.I.T. to an audience of their peers and prominent researchers alike. Participation in this program has afforded me the opportunity to combine my love of scientific research with the ability to mentor future generations of scientists, and has been truly rewarding.

Publications:

11. Mills, J.H.; Khare, S.D.; Bolduc, J.M.; Forouhar, F.; Mulligan, V.K.; Lew, S.; Seetharaman, J.; Tong, L.; Stoddard, B.L.; Baker, D.; “Computational Design of an Unnatural Amino Acid Mediated Metalloprotein with Atomic Level Accuracy” Journal of the American Chemical Society 2013, 135, 13393.

10. Gordon, S.R.; Stanley, E.J.; Wolf, S.; Toland, A.; Wu, S.J.; Hadidi, D.; Mills, J.H.; Baker, D.; Pultz, I.S.; Siegel, J.B.; “Computational Design of an -Gliadin Peptidase” Journal of the American Chemical Society 2012, 134, 20513.

9. Harger, M.; Zheng, L.; Moon, A.; Ager, C.; An, J.H.; Choe, C.; Lai, Y.; Mo, B.; Zong, D.; Smith, M.D.; Egbert, R.G.; Mills, J.H.; Baker, D.; Pultz, I.S.; Siegel, J.B. “Expanding the Product Profile of a Microbial Alkane Biosynthetic Pathway” ACS Synthetic Biology 2012, 2, 59.

8. Wu, S.J.; Eiben, C.B.; Carra, J.H.; Huang, I.; Zong, D.; Liu, P.; Wu, C.T.; Nivala, J.; Dunbar, J.; Huber, T.; Senft, J.; Schokman, R.; Smith, M.D.; Mills, J.H.; Friedlander, A.M.; Baker, D.; Siegel, J.B.; “Improvement of a Potential Anthrax Therapeutic by Computational Protein Design” Journal of Biological Chemistry 2011, 286, 32586.

7. Mills, J.H.; Lee, H.S; Liu, C.C.; Wang, J.; Schultz, P.G. “A Genetically Encoded Direct Sensor of Antibody-Antigen Interactions” ChemBioChem 2009, 10, 2162.6. Liu, C.C.; Mack A.V.; Brustad E.M.; Mills J.H.; Groff D.; Smider V.V.; Schultz P.G. “Evolution of Proteins with Genetically Encoded ‘Chemical Warheads’” Journal of the American Chemical Society 2009, 131, 9616.

5. Liu, C.C.; Mack A.V.; Tsao M.L.; Mills, J.H.; Lee, H.S.; Choe, H.; Farzan, M.; Schultz, P.G.; Smider, V.V. “Protein Evolution with an Expanded Genetic Code” Proceedings of the National Academy of Sciences U.S.A. 2008, 105, 17688.

4. Kavrakova, I.K.; Mills, J.H. “Lewis Acid Promoted Kharasch-type Additions of 3-bromoacetyl-2-oxazolidinone to Cycloalkenes” Journal of Chemical Research 2005, 2005, 59.

3. Yin, J.; Mills, J.H.; Schultz, P.G. “A Catalysis Based Selection for Peroxidase Antibodies with Increased Activity.” Journal of the American Chemical Society 2004, 126, 3006.

2. Pratt, D.A.; Mills, J.H.; Porter, N.A. “Theoretical Calculations of Carbon—Oxygen Bond Dissociation Enthalpies of Peroxyl Radicals Formed in the Autoxidation of Lipids.” Journal of the American Chemical Society 2003, 125, 5801.

1. Orihuela, C.J.; Mills, J.H.; Robb, C.W.; Wilson, C.J.; Watson, D.A.; Niesel, D.W. “Streptococcus pneumoniae PstS Production is Phosphate Responsive and Enhanced During Growth in the Murine Peritoneal Cavity.” Infection and Immunology 2001, 69, 7565.