Justin Siegel

Justin B. Siegel

siegeljb@uw.edu

My scientific interests are in combining computational and experimental tools to develop a fundamental knowledge of enzyme catalysis, and applying those principles to design novel proteins of therapeutic or commercial interest. Outside of the lab I am enjoying life with my wife (Juliet), dog (JJ), and new baby girl, Josefina!

For more information about me please visit my linked in profile.

Peer Reviewed Publications

Siegel J.B. et al. Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science 2010: 329: 309-313. DOI: 10.1126/science.1190239
Wu S.J., Eiben C.B., Carra J.H., Huang I., Zong D., Liu P., Wu C., Nivala J., Dunbar J., Huber T., Senft J., Schokman R., Smith M.D., Mills J.H, Friedlander A.M., Baker D., Siegel J.B. Improvement of a potential anthrax therapeutic by computational protein design. JBC 2011: 286: 32586-32592. DOI: 10.1074/jbc.M111.251041
Siegel J.B.*, Eiben C.B.*, Bale J., Foldit Players, Khatib F., Cooper S., Shen B.W., Stoddard B.L., Popovic Z., Baker D. Increased Diels-Alderase activity through FoldIt player guided backbone remodeling. Nature Biotechnology (2012). doi:10.1038/nbt.2109.

Patents and Company Bulletins

Siegel J.B., Baker D, Lidstrom M, Lee A, Louw C. Systems And Methods For Biotransformation Of Carbon Dioxide Into Higher Carbon Compounds. Patent Filed September 2011. United States Application Number: PCT/US2011/051847
Kashiyama Y, Yoshikuni Y, Baker D, Siegel J.B. Biofuel Production. United States Application Number: PCT/US2008/078844
Baker D., Zangellini A., Siegel J.B., Saint-Clair J. Enzyme catalysts for diels-alder reactions. United States Application Number: PCT/US2009/065127
Applied Biosystems Inc. Technical Bulletins (2001)

Recent Press

Crowdsourcing Computational Enzyme Design

Nature News: Victory for crowdsourced biomolecule design

CNET News: Crowdsourcing gamers best computers on protein folding

Bio Architecture Labs Featured on Cover of Science

Science Article: An Engineered Microbial Platform for Direct Biofuel Production from Brown Macroalgae

Nature News: Biofuel from beneath the waves

San Francisco Chronicle: Bio Architecture Lab sees seaweed in biofuels

Fortune Magazine/CNN Money: 4 new ways to solve the energy challenge

2011 UW iGEM Wins World Championship.

Decoding unselfishness - the double-helix of enthusiasm

Engineered critters bring 'world' title to UW team