Role of the biomolecular energy gap in protein design, structure, and evolution.

TitleRole of the biomolecular energy gap in protein design, structure, and evolution.
Publication TypeJournal Article
Year of Publication2012
AuthorsFleishman, S. J., & Baker D.
JournalCell
Volume149
Issue2
Pagination262-73
Date Published2012 Apr 13
ISSN1097-4172
KeywordsAnimals, Energy Metabolism, Evolution, Molecular, Humans, Models, Molecular, Nucleic Acids, Primary Publication, Protein Interaction Maps, Proteins
Abstract

The folding of natural biopolymers into unique three-dimensional structures that determine their function is remarkable considering the vast number of alternative states and requires a large gap in the energy of the functional state compared to the many alternatives. This Perspective explores the implications of this energy gap for computing the structures of naturally occurring biopolymers, designing proteins with new structures and functions, and optimally integrating experiment and computation in these endeavors. Possible parallels between the generation of functional molecules in computational design and natural evolution are highlighted.

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http://www.ncbi.nlm.nih.gov/pubmed/22500796?dopt=Abstract

Alternate JournalCell