Progress in modeling of protein structures and interactions

TitleProgress in modeling of protein structures and interactions
Publication TypeJournal Article
Year of Publication2005
AuthorsSchueler-Furman, O., Wang C., Bradley P., Misura K., & Baker D.
JournalScience
Volume310
Issue5748
Pagination638-42
Date Published2005 Oct 28
ISSN1095-9203
KeywordsComputer Simulation, Computing Methodologies, Models, Molecular, Primary Publication, Protein Conformation
Abstract

The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.

Alternate JournalScience
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