khare

Broadly, I am interested in understanding protein sequence-structure-function relationships and their interplay with evolution. In the Baker lab, I am involved with projects concerning the design of enzymes and small-molecule binding proteins. The design of novel enzymes and binding proteins is not only of tremendous practical value for custom designed catalysts and biosensors, but is also a stringent test of our understanding of the fundamental biophysics of molecular recognition and catalysis.

Recent Results:

We have recently designed a new activity, organophosphate hydrolysis, into an existing enzyme, adenosine deaminase. (Nature Chemical Biology, in press)

We have obtained computationally designed binding proteins for two different small molecule ligands. (in progress)

For more details see: 

http://faculty.washington.edu/khares/