Graduate Training in Neuroscience
University of Washington
G. Stanley McKnight
Professor, Department of Pharmacology
Cyclic AMP and Calcium Mediated Signal Transduction Protein kinases play an essential role in intracellular regulation by phosphorylating key substrates such as ion channels, enzymes, transcription factors, and cytoskeletal proteins. Phosphorylation can reversibly alter the biological activity of these substrates allowing a neuron to rapidly adapt to neurotransmitter and neuromodulator signals. Our laboratory is using the techniques of molecular genetics to study the cAMP and calcium regulated kinases that are expressed in brain. A current focus concerns leptin signaling and the regulation of body weight.
Image of the neurons in the hypothalamus that express the leptin receptor ( red) and the neurons that express the RIIbeta subunit of PKA (green). The image shows the arcuate nucleus at the bottom and the VMH near the top of the picture on either side.