Graduate Training in Neuroscience
University of Washington
Professor, Department of Pharmacology
My research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. We have identified a family of A-kinase–anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the specificity of second messenger–mediated signal transduction events by targeting enzymes close to their appropriate effectors and substrates. Our lab has made progress on establishing the AKAP model, the functional consequences of PKA anchoring, and the role of AKAP signaling complexes in the coordinate regulation of certain synaptic and cytoskeletal signaling events.