Module 3

Osteogenesis Imperfecta - The Consequence of a Genetic Mutation

Purpose: to extend the concepts introduced in the first two modules by showing how a single nucleotide substitution in a collagen gene can lead to severely weekend bones.

Instructional Approach:

This module was conceived and designed to use disease as a model for studying biology. The disease, Osteogenesis Imperfecta (OI), is dramatically introduced on the first day by showing the students an actual x-ray film of a neonate suffering from OI; the students are asked to observe the film and answer the question: "What's wrong with this picture?" The answer, the students will find, is that while traversing the birth canal, every single one of the infant's bones had broken.

This approach poses a real-world problem first, engaging the students and stimulating interest in the problem, and then asks them to develop and apply their understanding of normal biological function to understand what is wrong in the disease state.

Resources:

• Introduction Lecture PowerPoint
• Introduction Lecture Notes
• Genotype-Phenotype Lecture
• Inheritence Lecture
• Pathogenesis1 Lecture
• Pathogenesis2 Lecture (very large file)

• Disease Lab
• Modeling Lab
• Relevant Terms - in class exercise
• Understanding Disease - in class exercise

• Genotype/Phenotype Homework1
• Genotype/Phenotype Homework2
• Genotype/Phenotype Homework3
• Marfan's Syndrome Homework1
• Marfan's Syndrome Homework2
• Take Home Exam
• Project Grading Form

 

This project was funded by a grant from the NSF Action Agenda Program.
This site archives the original version of the course. For more information on
how the course is taught today, please visit: http://www.biologyforengineers.org

Copyright © 2005 BIOAA All Rights Reserved Webmaster