The event marked the third year the UW Institute for Stem Cell and Regenerative Medicine visited Mill Creek Middle School to lead activities designed to teach students about science and health.
Deok-Ho Kim receives $1.7M NIH R01 to develop tissue engineered human neuromuscular junctions for modeling axonal neuropathy
In this project, Dr. Kim and colleagues will apply novel stem cell and tissue engineering strategies to investigate underlying etiology of a common debilitating peripheral neuropathy (Charcot-Marie-Tooth disease; CMT).
SoundBio is currently funded via a National Science Foundation (NSF) grant awarded to UW Bioengineering Associate Professor Herbert Sauro to support its science education and outreach efforts.
Łukasz Ambroziński, Shaozhen Song, Soon Joon Yoon, Ivan Pelivanov, David Li, Liang Gao, Tueng T. Shen, Ruikang K. Wang, Matthew O’Donnell. Scientific Reports, 6: 38967 (2016). The researchers demonstrate acoustic micro-tapping – the use of focused ultrasound propagating in air to generate transient mechanical waves – as a non-invasive approach to dynamic elastography for mapping the elasticity of biological tissue without any physical contact. They propose to use it with 4-D phase-sensitive optical coherence tomography to create a tool for ophthalmology, dermatology and other applications where direct contact with the tissue being studied may be undesirable.
Lisa K. Lafleur, et al. Lab on a Chip, 2016, 16, 3777-3787. The researchers demonstrate a prototype of MAD NAAT, the first fully integrated, sample-to-result diagnostic platform for performing nucleic acid amplification texts that require no permanent instrument or manual sample processing.
Microvascular Injury and Perfusion Changes Induced by Ultrasound and Microbubbles in a Machine-Perfused Pig Liver
Christina P. Keravnou, Ine De Cock, Ine Lentacker, Maria-Louisa Izamis, Michalakis A. Averkiou. Ultrasound in Medicine & Biology, 2016 Nov;42(11):2676-2686. The researchers combined ex vivo machine-perfused pig livers with an image-guided therapy system to investigate applications of ultrasound-driven microbubbles to enhance drug delivery, and demonstrate a versatile, physiologically relevant platform for pre-clinical research.
Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation
Mu-En Lin, Theodore M. Chen, Mary C. Wallingford, Ngoc B. Nguyen, Shunsuke Yamada, Chenphop Sawangmake, Jaimei Zhang, Mei Y. Speer, Cecilia M. Giachelli. Cardiovascular Research. The researchers investigate the importance of Runx2 (runt-related transcription factor-2) in turning vascular smooth muscle cells into bone and cartilage cells, contributing to arterial intimal calcification, a condition implicated in atherosclerosis and may contribute to heart attack, stroke and other cardiovascular events.
Barrett J. Nehilla, John J. Hill, Selvi Srinivasan, Yen-Chi Chen, Thomas H. Schulte, Patrick S. Stayton, and James J. Lai. Analytical Chemistry. 2016, 88 (21), 10404–10410. The researchers present a stimuli-responsive binary reagent system, and how it illustrates the potential advantages of nanoscale reagents in molecule and cell isolations for both research and clinical applications.
Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue
Jia-Ling Ruan, Nathaniel L. Tulloch, Maria V. Razumova, Mark Saiget, Veronica Muskheli, Lil Pabon, Hans Reinecke, Michael Regnier, Charles E. Murry. Circulation. 2016; 134:1557-1567. The researchers demonstrate how electric pacing and mechanical stimulation promote maturation of the structural, mechanical and force generation properties of human-induced pluriopotent stem cell-derived cardiac tissues.
Y. Cheng, R. C. Yumul, S. H. Pun, Angewandte Chemie International Edition. 2016, 55, 12013. Researchers demonstrate a synthetic polymer, VIPER, designed to mimic viral mechanisms of delivery, and that may have potential as a gene delivery platform for cancer therapy and other macromolecule therapeutics.