Lawrence Crum, Research Professor

Thrust Area
Imaging and Image-Guided Therapy

Education
PhD (physics), University of Ohio, 1967
MS (physics), University of Ohio, 1965
BS (mathematics), University of Ohio, 1963

Research Interests
    •  Medical Imaging
    •  Physical Acoustics
    •  Industrial Acoustics
    •  Sonoluminescence

Contact Information
Center for Industrial and Medical Ultrasound
Applied Physics Laboratory
1013 NE 40th Street
Box 355640
Seattle, WA 98105
Phone: 206-685-8622
Fax: 206-685-8621
E-mail: lac@apl.washington.edu
Web site: http://cimu.apl.washington.edu/

Research Description

A list of the research projects in which I am currently involved with are:

• Acoustic Hemostasis
  the use of High Intensity Focused Ultrasound (HIFU) to stop bleeding
• Image-guided HIFU Therapy
  the use of ultrasound-guidance to generate HIFU lesions in vivo
• Extracorporeal Shock Wave Lithotripsy
  the use of acoustic shock waves to comminute kidney stones
• Ultrasound-Enhanced Drug Delivery
  the use of ultrasound to accelerate the transport of drugs, in both intra-vascular and transdermal applications
• The Physics of Ultrasound Contrast Agents
  the use of stabilized microbubbles to enhance echogenicity in diagnostic ultrasound devices
• Single Bubble Sonoluminescence
  the study of how ultrasound can generate light
• Sonochemistry and Toxic Waste Remediation

Honors and Awards

Selected Publications

• Therapeutic Ultrasound, Proceedings of the 2nd International Symposium, M.A. Andrew, L.A. Crum and S. Vaezy, eds (American Institute of Physics Press), 2003.
• Image-guided acoustic hemostasis, L. A. Crum, M. R. Bailey, Carter S, Curra F, Kaczkowski P, Kargl S, In: "New Acoustics: Selected Topics," C. Ranz-Guerra and J. A. Gallego-Juarez, eds., (Consejo Superior de Investigaciones Cientificas, Madrid), pp 26-36 (2002).
• Sonochemistry and Sonoluminescence, L. Crum, T. Mason, J. Reisse, and K. Suslick, eds., NATO ASI Series, Vol. 524 (Kluwer Academic Publishers: Dordrecht), 1999.
• The Sound of the Future: A Global View of Acoustics in the 21st Century, (Proceedings of the 16th International Congress on Acoustics and the 135th meeting of the Acoustical Society of America), P. K. Kuhl and L. A. Crum, eds., (American Institute of Physics: New York), 1998, pp. 3042.
• Shocking Revelations, L. A. Crum and T. J. Matula, Science, 276, 1348-1349 (1997).
• Hemostasis using High Intensity Focused Ultrasound, S. Vaezy, R. Martin, P. Mourad, and L. A. Crum, European J. of Ultrasound, 9, 79-87 (1999).
• Evidence for gas exchange in single bubble sonoluminescence, T. J. Matula and L. A. Crum, Phys. Rev. Letts. 80, 865-868 (1998).
• Bubbles hotter than the sun, L. A. Crum, New Scientist, 146, 36-41 (1995).
• Liver hemostasis using high intensity focused ultrasound, S. Vaezy, R. Martin, U. Schmiedl, M. Caps, S. Taylor, K. Beach, S. Carter, P. Kaczkowski, G. Keilman, S. Helton, W. Chandler, P. Mourad, M. Rice, R. Roy, and L. Crum, Ultrasound in Med. and Biol. 23, 1413-1420 (1997).
• Therapeutic ultrasound: Surgery and drug delivery, F. P. Curra, and L. A. Crum, Acoustical Science and Technology, 24 (6), 343-348 (2003).
• Pulsed high-intensity focused ultrasound-induced endothelial cell injury in vessels infused with ultrasound contrast agent, Hwang JH, A. A. Brayman, and S. Vaezy, In M. A. Andrew, L. A. Crum, and S. Vaezy, eds, Proc 2nd International Symp on Therapeutic Ultrasound, Seattle, WA, 63-71 (2003).
• High-intensity focused ultrasound: A potential new treatment for gastrointestinal bleeding, J. H. Hwang, S. Vaezy, R. W. Martin, M. Y. Cho, M. L. Noble, L. A. Crum, and M. B. Kimmey, Gastrointestinal Endoscopy, 58, 111-115 (2003).
• Cavitation bubble cluster activity in the breakage of kidney stones by lithotripter shock waves, Y. A. Pishchalnikov, O. A. Sapozhnikov, J. C. Williams, A. P. Evan, J. A. McAteer, R. O. Cleveland, T. Colonius, M. R. Bailey, and L. A. Crum, J Endourology, 17 (7), 435-446 (2003).