Research Interests
• Surface Analysis
• Surface Modification
• Biomaterials
• Microarray Chemistry
Contact Information
Department of Bioengineering
University of Washington
Box 351750
Phone: 206-616-4173
Fax: 206-543-3778
E-mail: gamble@nb.engr.washington.edu
Web Site: http://www.nb.engr.washington.edu
Research Description
My research focuses on surface modification and characterization of model biomedical systems. Most recently my focus has been on fundamental research towards the preparation and characterization of DNA and protein microarrays. I am also involved in the development of new techniques that will enable improved analysis of the biomolecule-surface interface.
Professional Experience
2000-2001 Research Scientist, Zyomyx, Inc., Hayward, CA
2001-2003 Senior Scientist, USU Space Dynamics Laboratory, North Logan, UT
2003-Present NESAC/BIO Research Coordinator, Dept. of Bioengineering, University of Washington 2004–Present Research Assistant Professor, Dept. of Bioengineering, Univ. of Washington
2004-Present NESAC/BIO Assistant Director, Dept. of Bioengineering, Univ, of Washington
2004-Present SARC Assistant Director, Dept. of Bioengineering, Univ. of Washington, Seattle, WA
Selected Activities and Honors
1993 David M. Ritter Graduate Student Award
2006-2007 Chair, AVS Local Arrangements Committee (AVS 54 th Intl. Symposium, Seattle 2007)
2007-2008 Chair, SFB Surface Characterization and Modification Special Interest Group
2008 Organizer, Surface Characterization of Biomaterials, 8th World Biomaterials Congress ( Amsterdam, The Netherlands)
Selected Publications
- C.-Y. Lee, P. Gong, G.M. Harbers, D.W. Grainger, D.G. Castner, and L.J. Gamble, "Surface Coverage and Structure of Mixed DNA/Alkylthiol Monolayers on Gold: Characterization by XPS, NEXAFS, and Fluorescence Intensity Measurements", Anal. Chem., 78, p3316-3325, 2006.
- P. Gong, C.-Y. Lee, L.J. Gamble, D.G. Castner, and D.W. Grainger, "Hybridization Behavior of Mixed DNA/Alkylthiol Monolayers on Gold: Characterization by Surface Plasmon Resonance and 32P Radiometric Assay", Anal. Chem., 78, p3326-3334, 2006.
- M. Ciobanu, A. Siove, V. Gueguen, L.J. Gamble, D.G. Castner, and V. Migonney, "Radical graft polymerization of styrene sulfonate on poly(ethylene terephthalate) films for ACL applications: "Grafting from" and chemical characterization", Biomacromolecules, 7 (3) p755-760, 2006.
- C. -Y. Lee, G. M. Harbers, D. W. Grainger, L. J. Gamble, and D. G. Castner, “Fluorescence, XPS, and ToF-SIMS Surface Chemical State Image Analysis of DNA Microarrays”, J. Am. Chem. Soc. 129 (30), p9429-9438, 2007.
- C. -Y. Lee, P-C. Nguyen, D. W. Grainger, L. J. Gamble, and D. G. Castner, “Structure and DNA Hybridization Properties of Mixed Nucleic Acid/Maleimide-ethylene glycol Monolayers”, Anal. Chem. 79 (12), p4390-4400, 2007.
- U. Makal, L. Gamble, P. Kurt, and K. J. Wynne, “Model Polyurethane Polymeric Surface Modifiers Having Semifluorinated and Bromomethyl Co-polyoxetane Soft Blocks”, Langmuir (in press 2007).
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