Research Interests
• Tissue engineering
• Calcification
• Cell-material interactions
• Foreign body response
• Ectopic calcification
Contact Information
Department of Bioengineering
University of Washington
Box 355061
William H. Foege Building, Room N330L
Phone: 206-543-0205, 206-221-5826
Fax: 206-616-9763
E-mail: ceci@u.washington.edu
Research Description
Current projects include 1) identifying and applying biomimetic strategies to cell-substrate interactions important for promoting endothelial survival and angiogenesis particularly in the context of biomaterial healing, 2) biomolecular control of the foreign body reaction, with particular emphasis on the macrophage-mediated inflammatory response to biomaterials, 3) mechanistic studies aimed at developing novel therapeutic targets and approaches for preventing ectopic calcification in disease and medical devices 4) cardiac valve and esophageal tissue engineering.
Teaching Activities
- BIOEN 510: Introduction to Bioengineering
- BIOEN 599B: UWEB Seminar
- BIOEN 579: Host Response to Biomaterials
- BIOEN 357: Introduction to Molecular Bioengineering
- BIOEN 586: Tissue Engineering (Cell and Matrix Modules)
- BIOEN 490: Introduction to Biomaterials (Foreign Body Reaction Modules)
Professional Experience
| 1998 |
Pharmacology Postdoctoral Fellow, University of Washington |
| 1998-99 |
Pathology Postdoctoral Fellow, University of Washington |
| 1990 |
Research Associate, University of Washington |
| 1991-92 |
Lecturer, University of Washington |
| 1992-97 |
Research Assistant Professor, University of Washington |
| 1997-98 |
Research Associate Professor, Department of Bioengineering, University of Washington |
| 1998- |
Associate Professor, Department of Bioengineering, University of Washington |
| 1998- |
Deputy Director, University of Washington Engineered Biomaterials (UWEB) |
Honors and Awards
| 1982 |
Departmental Citation in Biochemistry, University of California at Davis |
| 1982 |
Highest Honors, University of California – Davis |
| 1985 |
Pacific Northwest Association of Toxicologists’ Outstanding Graduate Student Presentation Award |
| 1982-88 |
Pacific NIEHS Environmental Pathology/Toxicology Training Grant, University of Washington |
| 1988-89 |
Pacific NIH Cardiovascular Pathology Training Grant |
| 1996-01 |
American Heart Association Established Investigator Award |
| 2003 |
Advances in Mineral Metabolism Investigator Award |
Selected Publications
- Giachelli CM, Bae N, Almeida M, Denhardt DT, Alpers CE, Schwartz SM. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest 92:1686-1696, 1993.
- Liaw L, Skinner MP, Raines EW, Ross R, Cheresh DA, Schwartz SM, Giachelli CM. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins: Role of avb3 in smooth muscle migration to osteopontin in vitro. J Clin Invest 95:713-724, 1995.
- Giachelli CM, Lombardi D, Johnson RJ, Murry CE, Almeida M. Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Amer J Pathol 152: 353-358, 1998.
- Wada T, McKee MD, Steitz S, Giachelli CM. Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin. Circ Res 84: 166-178, 1999. Jono S, Peinado C., Giachelli CM. Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification. J Biol Chem 275:20197-20203, 2000.
- Jono S, McKee, MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM. Phosphate regulation of vascular smooth muscle calcification. Circ Res 87:e10-e17, 2000
- Steitz SA, Speer MY, Curinga G, Ying-Yang H, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli CM. Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa-1 and down-regulation of smooth muscle lineage markers. Circ Res, 2001
- Steitz SA, McKee MD, Liaw L, Giachelli CM. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Amer J Path 16:2035-2046, 2002
- Speer MY, McKee MD, Guldberg RE, Liaw L, Yang HY, Tung E, Karsenty G, Giachelli CM. Inactivation of the osteopontin gene enhances vascular calcification of matrix gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 196: 1047-1055, 2002
- Wiester LM, Giachelli CM. Expression and function of the integrin, a9b1, in bovine aortic valve interstitial cells. J Heart Valve Disease, 12: 605-616, 2003
- Cuy JL, Beckstead BL, Brown CD, Hoffman AS, Giachelli CM. Adhesive protein interactions with chitosan: consequences for valve endothelial cell growth on tissue-engineering materials. J Biomed Mater Res, 67A: 538-547, 2003.
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