Research Interests
• Smart polymer bioconjugates
• Hydrogels
• Drug delivery
• Polymer surfaces
Contact Information
Department of Bioengineering
University of Washington
Box 355061
William H. Foege Building, Room N530R
Phone: 206-543-9423
Fax: 206-543-6124
E-mail: hoffman@u.washington.edu
Research Description
The major activities in my laboratories include the following:
- SMART POLYMER BIOCONJUGATES: Synthesis, characterization and application of site-specific conjugates of smart polymers and genetically engineered proteins. Applications include affinity separations, diagnostics, biosensors, bioprocessors, and drug delivery.
- HYDROGELS: Synthesis and characterization of natural polymer hydrogels for use as tissue engineering matrices or as coatings for implants (to enhance implant healing and integration). We may incorporate various drugs into the matrices (also cells, when the matrix is for use as a tissue-engineering scaffold). The matrices are designed to be biocompatible and biodegradable.
- DRUG DELIVERY: design and synthesis of acid sensitive polymers for incorporation into drug delivery formulations where acidic environments are encountered during delivery. Currently, the polymers are specifically designed to facilitate the escape of fragile drugs, such as DNA, ODNs, peptides and proteins, from the endosome to the cytosol before the drugs are trafficked to lysosomes, where enzymes would degrade them.
- POLYMER SURFACES: Surface modification and characterization of polymeric biomaterials. Surfaces are modified with plasma gas discharge treatments to make them more or less chemically reactive or bioreactive. Biomolecules may be immobilized on the treated surfaces. This is relevant to biomedical implants, as well as for applications in affinity separations, diagnostics, biosensors, bioprocessors, and drug delivery.
Teaching Activities
- BIOEN 491: Drug Delivery Systems
- BIOEN 490: Biomaterials
- BIOEN 590: Advanced Biomaterials
- BIOEN 511: Biomaterials Seminar
Honors and Awards
| 1957 |
Flullbright Fellowship, Paris, France |
| 1977 |
Chairman, Gordon Conference on Biomaterials |
| 1983 |
President, Society for Biomaterials |
| 1984 |
Clemson Award for "Contributions to the Scientific Literature on Biomaterials" |
| 1986-89 |
Trustee and Member, Board of Directors of the International Society of Artificial Organs |
| 1987-89 |
Member, Surgery and Bioengineering Study Section, NIH, Bethesda, MD |
| 1990 |
Special Recognition Award for "Excellence in Guiding Graduate Student Research", Controlled Release Society, Chicago, IL |
| 1990 |
Biomaterials Science Prize, Japanese Society for Biomaterials, Tsukuba, Japan |
| 1991-94 |
Board of Governors, Controlled Release Society |
| 1992 |
Founding Fellow of American Institute of Medical and Biological Engineering (AIMBE) |
| 1992 |
Symposium in honor of 60th birthday, Maui, Hawaii |
| 1993-94 |
Festschrift in honor of 60th birthday, J. Biomaterials Science, Polymer Edition (book published from Festschrift in 1955) |
| 1997 |
Alan S. Michaels Lectureship, MIT |
| 1999 |
Special Recognition Award for "Excellence in Guiding Graduate Student Research", Controlled Release Society, Boston, MA |
| 2000 |
Founder's Award, Society for Biomaterials, 6th World Congress on Biomaterials, Maui, Hawaii |
| 2002 |
Symposium in honor of 70th Birthday, Maui, Hawaii |
| 2005 |
Elected to National Academy of Engineering for "Pioneering Work on the Medical Uses of Polymeric Materials" |
Selected Publications
- Ratner, B.D., A.S. Hoffman, F.J. Schoen, and J.E. Lemons, Eds., "Biomaterials Science: An Introduction to Materials in Medicine", 2 nd Edition, Elsevier/Academic Press, NY, NY (2004).
- Stayton, P.S., Ding, Z. and Hoffman, A.S., “Smart polymer-streptavidin conjugates”, Methods Mol Biol. 283: 37-44 (2004).
- T. Kiang, C. Bright, C.Y. Cheung, P.S. Stayton, A.S. Hoffman and K.W. Leong, “Formulation of Chitosan/DNA Nanoparticles with Poly(propylacrylic acid) Enhances Gene Expression”, J. Biomater. Sci, Pol. Ed,, 15, 1405-1422 (2005)
- D. Pack, A.S. Hoffman, S. Pun and P.S. Stayton, “Design and Development of Polymers for Gene Delivery”, Nature Reviews, Drug Discovery, 4, 581-593 (2005)
- A.S. Hoffman, “Selecting the Right Polymer for Biomaterial Applications”, Chapter 1 in “Drug Delivery”, ed. I. F. Uchegbu, Taylor & Francis, London (2006) p 7-23.
- M. Ebara, J.M. Hoffman, A.S. Hoffman, and P.S. Stayton, “Switchable surface traps for injectable bead-based chromatography in PDMS microfluidic channels”, Lab Chip, 6(7), (2006).
- X. Yin, P.S. Stayton and A.S. Hoffman, “Temperature- and pH-Responsiveness of Poly(N-Isopropylacrylamide-co-Propylacrylic acid) Copolymers Prepared by RAFT Polymerization” Biomacromol., 7, 1381-5 (2006).
- S.M. Henry, M.E.H. El-Sayed, C.M. Pirie, P.S. Stayton, and A.S. Hoffman, “pH-Responsive Poly(styrene-alt-maleic anhydride) Copolymers for Intracellular Drug Delivery”, Biomacromol., 7, 2407-14 (2006).
- S. Kulkarni, C. Schilli, B. Grin, A.H.E. Müller, A.S. Hoffman, and P.S. Stayton, “Controlling the Aggregation of Conjugates of Streptavidin with Smart Block Copolymers Prepared via the RAFT Copolymerization Technique”, Biomacromol., 7, 2736-41 (2006)
- Narain , R., Gonzales , M., Hoffman, A.S., Stayton , P.S., and Krisnan , K.M., "Synthesis of Monodisperse Biotinylated p(NIPAAm)-Coated Iron Oxide Magnetic Nanoparticles and their Bioconjugation to Streptavidin", Langmuir 23(11); 6299-6304 (2007)
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