Research Interests
• Biomaterials
• Wound healing
• Angiogenesis
• Tissue engineering
Contact Information
Department of Bioengineering
University of Washington
Box 355061
William H. Foege Building, Room N310D
Phone: 206-543-5789
Fax: 206-616-9763
E-mail: mscatena@u.washington.edu
Research Description
Angiogenesis, the formation of capillaries from pre-existing blood vessels, occurs as a result of various normal and pathological processes, including ovulation, wound healing and ischemic disease. Furthermore, impaired angiogenesis is a common problem in healing of implanted medical devices. In my group we focus on several aspects of the relationship between the extracellular matrix and the angiogenesis process. One project investigates the intracellular signaling events initiated and regulated by the extracellular matrix and its cellular receptors in vascular cells. A second project explores how the extracellular matrix regulates cell survival, in particular survival of endothelial cells, which are the "building blocks" of new capillaries. A third project focuses on methods to improve the vascular network around implanted biomaterials. Target applications are therapeutic angiogenesis, and tissue engineering.
Honors, Awards and Professional Activities
- 1991: Bayrofarm Italia Fellowship
- 1992: Anna Villa Rusconi Fellowship
- 1992: EMBO Short Term Fellowship
- 1993: University of Padova Fellowship for Training Abroad
Selected Publications
- Pritzker L.B., Scatena M., Giachelli C.M. The role of osteoprotegerin and TNF-related apoptosis inducing ligand in human microvascular endothelial cell survival. Mol.Biol.Cell 2004; in press.
- Iurlaro, M., Scatena, M., Wieting S.L., Zhu, W.H., Nicosia R.F. Rat aorta-derived mural precursor cells express the Tie2 receptor and respond directly to stimulation by angiopoietins. J Cell Sci. 2003; 116:3635-43.
- Ismail JA, Poppa V, Kemper LE, Scatena M, Giachelli CM, Coffin JD, Murry CE. Immunohistologic labeling of murine endothelium. Cardiovasc Pathol. 2003 Mar-Apr; 12(2):82-90.
- Iurlaro M., Sanders J.E., Zhu W.H., Scatena M., Mitchell S.B., Nicosia R.F. Use of Vascular Explants for Ex Vivo Neovascularization of Biomaterials. 2002 Microvascular Research 64:398-404
- Scatena, M., Giachelli C.M. The alpha-v beta-3 integrin, NF-kappaB, osteoprotegerin endothelial cell survival pathway 2001. Trends in Cardiovascular Medicine. Trends in Cardiovascular Medicine. 2001 (in press)
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