Research Interests
• Therapeutic ultrasound (HIFU)
• Hemostasis
• Uterine fibroids
• Liver bleeding
Contact Information
Department of Bioengineering
University of Washington
Box 355061
William H. Foege Building, Room N430L
Phone: 206-543-8533
Fax: 206-543-3702
E-mail: adasi@u.washington.edu
Website: http://faculty.washington.edu/adasi/
Research Description
My primary research focus is in the field of therapeutic ultrasound, where ultrasound is used for such purposes as tumor treatment. Specifically, we use High Intensity Focused Ultrasound (HIFU), in which high levels of energy, on the order of 1000 W/cm2, are delivered to the tissue. Such energy levels produce temperatures in excess of 60°C in about 1 second, resulting in tissue necrosis and structural/functional modification, all with the aim of a therapeutic benefit.
We are investigating several applications of HIFU. Hemostasis is an important application in which we use HIFU to stop bleeding from body organs such as liver and spleen as well as from blood vessels in trauma situations. An acoustic hemostasis device can provide life- and limb-saving measures for trauma patients. Another area of investigation is treatment of uterine fibroids, which are benign tumors of the uterus. An acoustic treatment for uterine fibroids would provide a non-invasive treatment option for women with this condition.
An important characteristic of ultrasound is its ability to penetrate tissues. HIFU can deliver a high level energy to deep-seated regions of tissue, where bleeding is occurring or tumors are residing. Such deep-tissue energy delivery allows for performing therapy without surgical exposure, while sparing the overlying or surrounding tissues from being significantly affected by the high energy. No other existing technique has this unique characteristic. Therapeutic ultrasound is an excellent example of bioengineering in action.
Current Research Projects
- Ultrasound Contrast Agents, UW, 2003-Present
Enhanced diagnosis and therapy using ultrasound contrast agents
- HIFU Arrays, UW, 2002-Present
Design, implementation, and testing of phased-array HIFU transducers
- Neurolysis for Spasticity and Pain, UW, 2001-Present
Image-guided HIFU for treatment of peripheral nerves in spinal cord injury patients
- Tissue-Mimicking Phantoms for Ultrasound Therapy, UW, 2000-Present
Polymer-based media with embedded proteins for in vitro testing
- Acoustic Coupling for Therapeutic Ultrasound, UW, 1999-Present
Novel Hydrogel-based coupling for surgical and extracorporeal ultrasound therapy
- Bioengineering Aspects of Image-Guided HIFU, UW, 1999-Present
Biological and physical mechanisms involved in image-guided HIFU therapy
- Intra-Operative Acoustic Hemostasis, UW, 1999-Present
Acoustic hemostasis surgical devices in the operating room
- Uterine Tumors, UW, 1998-Present
Image-guided treatment of uterine tumors using high intensity focused ultrasound
- Acoustic Hemostasis for Advanced Trauma Care, UW, 1996-Present
Image-guided high-intensity focused ultrasound for hemorrhage control in remote trauma management
Teaching Activities
- BIOEN 560: Biomedical Ultrasound, Bioengineering, Spring of Odd Years
- BIOEN 585: Image-Guided Therapy, Spring of Even Years
- Medical Ultrasound Journal Club, Every week, 1998-Present, Applied Physics Lab
Honors and Awards
- 2003: Cover of IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
- 2002: Science Writing Award for Professionals in Acoustics, Acoustical Society of America
- 2000: Best Video in Basic Science, American Society of Reproductive Medicine
- 2000: Paper Selected for the Yearbook of Vascular Surgery
- 1999: Prize Paper Award, The American Society of Reproductive Medicine
- 1999: Cover of the Journal of Trauma for Spleen Hemostasis Device
- 1998: Co-Author, Best Clinical Paper of the Year, Journal of Ultrasound in Medicine and Biology
- 1991-93: Vision Training Grant Postdoctoral Fellowship, National Institutes of Health
- 1988-91: Molecular Biophysics Pre-doctoral Fellowship, National Institutes of Health
- 1987: Research Assistant Scholarship, Center for Bioengineering, UW
- 1983-86: Wayland Scholarship, UW
- 1985: ALCOA (Aluminum Company of America) Scholarship, UW
Professional Experience
- 2002-Present: Associate Professor (WOT), Bioengineering, UW
- 2000-Present: Senior Engineer, Applied Physics Laboratory (APL), UW
- 1998-2003: Research Assistant Professor, Bioengineering, UW
- 1996-98: Senior Fellow, Anesthesiology, UW
- 1994-95: President, ADASI Research
- 1991-94: Post-doctoral Fellow, Biological Structure, UW
- 1986-1991: Pre-doctoral Research Assistant, Center for Bioengineering, UW
Selected Publications, Presentations, and Patents
- Chou S, Rabkin B, Dowling S, Vaezy S, Theiss P (2004) An immunocompetent orthotopic isograft mouse model of ovarian epithelial carcinoma for high-intensity focused ultrasound treatment. Comparative Medicine. In Press.
- Foley J, Little J, Starr F, Frantz C, and Vaezy S (2004) Image-Guided HIFU Neurolysis of Peripheral Nerves to Treat Spasticity and Pain, Ultrasound in Med Biol, In Press.
- Vaezy S, Vaezy S, Starr F, Chi E, Cornejo C, Crum L, Martin R (2004) Intra-Operative Acoustic Hemostasis of Liver: Production of a Homogenate for Effective Treatment, Ultrasonics, In Press.
- Chan A, Fujimoto V, Moore D, Held R, Paun M, Vaezy S, (2004) Image-guided transvaginal focused ultrasound therapy: In vivo feasibility and potential for leiomyoma treatment, Fertility and Sterility, In Press.
- Zderic V, Clark JI, Martin RW, Vaezy S (2004) Ultrasound-enhanced transcorneal drug delivery, Cornea, In Press.
- Cornejo CJ, Vaezy S, Jurkovich GJ, Paun M, Sharar SR, Martin RW (2004) High Intensity Ultrasound Treatment of Blunt Abdominal Solid Organ Injury: An Animal Model. J Trauma, 57(1): 152-156.
- Zderic V, Keshavarzi A, Andrew M, Vaezy S, and Martin R (2004) Attenuation of porcine tissues in-vivo after high intensity ultrasound treatment, Ultrasound Med Biol, 30(1):61-66.
- Vaezy S, Noble M, Keshavarzi A, Paun M, Prokop A, Cornejo C, Sharar S, Chi E, Crum L, and Martin R (2004) Liver Hemostasis using High Intensity Ultrasound: Repair and Healing, J Ultrasound in Medicine, 23:217-225.
- Paek BW, Vaezy S, Fujimoto V, Bailey M, Albanese CT, Harrison M, Farmer D (2003) Tissue Ablation using High Intensity Focused Ultrasound in the Fetal Sheep Model: Potential for Fetal Treatment, Am J Obstet Gynecol, 189(3):702-705.
- Martin R, Vaezy S, Proctor A, Myntti T, Lee J, Crum L (2003) Water Cooled High Intensity Ultrasound Surgical Applicators with Frequency Tracking, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 50(10):1305-1317.
- Chen W, Lafon C, Matula T, Vaezy S, and Crum L (2003) Mechanisms of lesion formation in high intensity focused ultrasound therapy, Acoustic Research Letters Online, 4(2):41-46.
- Prokop A, Vaezy S, Martin R, Noble M, Kaczkowski P, Martin R, and Crum L (2003) Polyacrylamide Gel as an Acoustic Coupling Medium for Focused Ultrasound Therapy, Ultrasound in Medicine and Biology, 29(19):1351-1358.
- Keshavarzi A, Vaezy S , Noble M, Paun M, Fujimoto V (2003) Treatment of Uterine Fibroid Tumors in an in-situ Rat model using High-Intensity Focused Ultrasound, Fertility and Sterility, 80(Supp2):761-767 .
- Hwang JH, Vaezy S, Martin RW, Cho MY, Noble ML, Crum LA, Kimmey MB (2003) High-intensity focused ultrasound: a potential new treatment for gastrointestinal bleeding, Gastrointestinal Endoscopy; 58(1):111-115.
- Chan A, Vaezy S, and Crum L (2003) High Intensity Focused Ultrasound, Yearbook of Science and Technology, McGraw-Hill Yearbook of Science and Technology, pp.173-175.
- Crum L, Bailey M, Carter S, Curra F, Kaczkowski P, Kargl S, Martin R, Mourad P, and Vaezy S (2002) Image-guided acoustic hemostasis in New Acoustics: Selected Topics, C. Ranz-Guerra and J. A. Gallego-Juarez, eds., (Consejo Superior de Investigaciones Cientificas, Madrid), pp 26-36.
- Chan A, Fujimoto V, Moore D, Martin R, Vaezy S (2002) An image-guided high intensity focused ultrasound device for uterine fibroid treatment, Med Phys, 29(11): 2611-2620.
- Noble M, Vaezy S, Keshavarzi A, Paun M, Prokop A, Chi E, Cornejo C, Sharar S, Jurkovich G, Martin R, and Crum L (2002) Spleen Hemostasis using High Intensity Ultrasound: Survival and Healing, J Trauma, 53(6):1115-20.
- Keshavarzi A, Vaezy S , Chi EY, Walker C, Martin RW, Fujimoto V (2002) Treatment of Uterine Leiomyosarcoma Tumors in a Nude Mouse Model using High-Intensity Focused Ultrasound: A Potential Treatment Modality for Recurrent Pelvic Disease, Gynecological Oncology, 86(3):344-50.
- Zderic V, Vaezy S, Martin R, Clark J (2002) Ocular Drug Delivery using 20 kHz Ultrasound, Ultrasound in Med Biol, vol. 28(6), pp. 823-829.
- Shi X, Martin R, Vaezy S, and Crum L (2002) Quantitative investigation of acoustic streaming in blood. Journal of Acoustical Society of America, vol. 111(2), pp. 1110-1121.
- Shi X, Martin R, Vaezy S, Kaczkowski P, and Crum L (2001) Color Doppler Detection of Acoustic Streaming in a Hematoma Model, Ultrasound in Med Biol, vol. 27(9), pp. 1255-1264.
- Vaezy S, Andrew M, Kaczkowski P, Crum L (2001) Image-Guided Acoustic Therapy, Annual Review of Biomedical Engineering, vol. 3:375-90.
- Keshavarzi A, Vaezy S, Kaczkowski P, Keilman G, Martin R, Chi E, Garcia R, Fujimoto V (2001) Attenuation Coefficient and Sound Speed in Human Myometrium and Uterine Fibroid Tumors, J Ultrasound in Medicine, vol. 20, pp. 473-480.
- Vaezy S, Martin R, Carter S, Keilman G, Fujimoto V, and Crum L, Ultrasound therapy head configured to couple to an ultrasound imaging probe to facilitate contemporaneous imaging using low intensity ultrasound and treatment using high intensity focused ultrasound, patent # 6,716,184.
- Vaezy S, Martin R, Carter S, Keilman G, Fujimoto V, and Crum L. Noise-Free Real Time Ultrasonic Imaging of a Treatment Site Undergoing High Intensity Focused Ultrasound Therapy, Patent # 6,425,867.
- Martin R, Crum L, Vaezy S, Beach K, Carter S, Helton S, Caps M, Kaczkowski P, Proctor A, Keilman G. Method and Apparatus for Medical Procedures using High Intensity Focused Ultrasound, 1999, Patent # 6,432,067.
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