BioEngineering

Xingde Li, Associate Professor

Thrust Areas
Medical Imaging and Image-Guided Therapy
Distributed Diagnosis and Home Healthcare

Education
PhD (physics and biomedical optics), University of Pennsylvania, 1998
BS (physics), University of Science and Technology of China, 1990

Research Interests
 Noninvasive optical "biospy" technologies, nano biophotonics, optical imaging and image-guided interventions, translational molecular imaging and early disease detection

Contact Information
Department of Bioengineering
University of Washington
Box 355061
William H. Foege Building, Room N430M
Phone: 206-616-4853
Fax: 206-685-3300 (shared)
E-mail: xingde@u.washington.edu

Research Description

Our research interest centers on development of translational biophotonics technologies that interface/bridge the basic engineering research and medical diagnosis/therapy. The research involves integration of multi-disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. Applications of the technologies include detection of diseases at early, manageable stages; monitoring therapeutic effects and treatment outcomes; and guiding excisional biopsy and surgical interventions. The compact, robust and low cost nature of the technologies and their capability of performing noninvasive virtual “optical biopsy” make them potentially powerful for point of care and global health applications.  

Technology focus:

  • Optical coherence tomography - OCT (noninvasive, real-time, high-resolution microanatomy and flow imaging);
  • Fluorescence tomography based on diffuse photons (molecular imaging);
  • Fiber-optic endomicroscopy (for two-photon fluorescence, second harmonic generation and OCT imaging);
  • Smart fluorescent polymeric nanocomplexes (micelles and nanoparticles) and bio-inert structured metallic nanocomplexex for translational molecular imaging, therapy and potentially controlled release.

Application focus:

  • Systematic ultrahigh-resolution imaging of internal organs (e.g. human esophagus) for early detection of epithelial and subsquamous (hidden) lesions and monitoring treatment outcomes;
  • Wound healing/tissue regeneration and influences/effects of stimuli;
  • Fine optical needle imaging for image-guided biopsy;
  • Non-destructive evaluation of materials and micro devices.

Teaching Activities

Active courses:

Courses previously developed and taught:

Honors and Awards

  • 2002: Distinguished Teacher/Mentor Award, Dept of Bioengineering, University of Washington
  • 2004: NSF Career Development Award

Selected Publications

  • H. Fu, M. J. Cobb, Y. X. Leng, J. H. Hwang, and X. D. Li, “Flexible miniature compound lens design for high-resolution OCT balloon imaging catheter,” Journal of Biomedical Optics - Letters, in press (2008).
  • J. Patterson, P. S. Stayton, and X. D. Li, “In situ characterization of the degradation of PLGA microspheres by optical coherence tomography,” IEEE Transactions on Medical Imaging, in press (2008).
  • V. Rodriguez, S. Henry, A. S. Hoffman, P. S. Stayton, X. D. Li, and S. H. Pun, “Enhanced stabilization of Indocyanine Green (ICG) with polymer micelles encapsulation,” Journal of Biomedical Optics 13(1):014025-1(2008).
  • D. L. Wang , B. V. Hunter, M. J. Cobb, and X. D. Li, "Super-Achromatic Rapid Scanning Microendoscope for Ultrahigh-Resolution OCT Imaging," IEEE Journal of Selected Topics in Quantum Electronics 13(6):1596-1601 (2007).
  • S. E. Skrabalak, L. Au, X. D. Li, and Y. N. Xia, "Facile synthesis of Ag nanocubes and Au nanocages," Nature Protocols 2(9):2182-2190 (2007).
  • J. Y. Chen, D. L. Wang, J. Xi, L. Au, A. Siekkinen, A. Warsen, Z. Y. Li, H. Zhang, Y. N. Xia, and X. D. Li, "Immuno Gold Nanocages with Tailored Optical Properties for Targeted Photothermal Destruction of Cancer Cells," Nano Letters 7(5):1318-1322 (2007).
  • M. J. Cobb, Y. C. Chen, R. Underwood, R. Thariani, M. Usui, J. E. Olerud, and X. D. Li, “Non-invasive assessment of cutaneous wound healing using high-resolution optical coherence tomography,” Journal of Biomedical Optics, 11(6):064002, 1-11 (2006).
  • M. J. Cobb, Y. C. Chen, S. Baily, C. Kemp, and X. D. Li, “Non-invasive detection of early neoplasia in carcinogen-induced skin cancer mouse models in vivo,” Cancer Biomarkers 2(3-4):163-173 (2006).
  • H. W. Ren, and X. D. Li, "Clutter rejection filters for optical Doppler tomography," Optics Express, 14(13):6103-6112 (2006).
  • M. T. Myaing, D. J. MacDonald, and X. D. Li, "Fiber-optic scanning two-photon fluorescence endoscope," Optics Letters 31(8):1076-1079 (2006).
  • H. W. Ren, T. Sun, D. J. MacDonald, M. J. Cobb, and X. D. Li, "Real-time in vivo blood flow imaging by moving scatterer sensitive spectral domain optical Doppler tomography," Optics Letters 31(7):927-929 (2006).
  • H. Cang, T. Sun, Z. Y. Li, J. Chen, B. J. Wiley, Y. N. Xia, and X. D. Li, "Gold nanocages as potential contrast agents for spectroscopic optical coherence tomography," Optics Letters 30(22):3048-3050 (2005).
  • Y. C. Chen, X. M. Liu, M. J. Cobb, M. T. Myaing, T. Sun, and X. D. Li, "Optimization of optical spectral throughput of acousto-optic modulators for high-speed optical coherence tomography," Optics Express 13(20):7816-7822 (2005).
  • J. Y. Chen, B. Wiley, Z. Y. Li, D. Campbell, F. Saeki, H. Cang, L. Au, J. Lee, X. D. Li, and Y. N. Xia, "Gold nanocages: Engineering their structure for biomedical applications," Advanced Materials 17( 18):2255-2261 (2005).
  • M. J. Cobb, X. M. Liu, and X. D. Li, "Continuous focus tracking for real-time optical coherence tomography," Optics Letters 30(13):1680-1682 (2005).
  • J. Y. Chen, F. Saeki, B. J. Wiley, H. Cang, J. M. Cobb, Z. Y. Li, L. Au, H. Zhang, M. B. Kimmey, X. D. Li, and Y. N. Xia, "Bioconjugated gold nanocages and evaluation of their potential for optical imaging and thermal therapeutic applications," Nano Letters 5(3): 473-477 (2005).
  • J. H. Hwang, M. J. Cobb, M. B. Kimmey, and X. D. Li, "Optical coherence tomography imaging of the pancreas: a needle-based approach," Clinical Gastroenterology and Hepatology 3(7 Suppl 1):S49-52 (2005).
  • Y. C. Chen, and X. D. Li, "Dispersion management for real-time optical coherence tomography involving a phase modulator," Optics Express 12 (24):5968-5978 (2004).
  • X. M. Liu, Y. C. Chen, M. J. Cobb, M. B. Kimmey, and X. D. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Optics Letters 29(15):1763-1765 (2004).
  • X. M. Liu , M.J. Cobb, and X.D. Li, “Rapid Scanning All-reflective Optical Line for Real-time Optical Coherence Tomography, Optics Letters 29(1):80-82 (2004).

Book Chapter

  • X. D. Li, and J. G. Fujimoto, “Optical Coherence Tomography,” in Encyclopedia of Biomaterials and Biomedical Engineering, Gary E. Wnek and Gary L. Bowlin, Eds., Marcel Dekker, Inc., New York, 2004.