Research Interests
• Optically-based, non-invasive imaging
• Spectroscopic techniques and their applications in biomedicine
Contact Information
Department of Bioengineering
University of Washington
Box 355061
William H. Foege Building, Room N430M
Phone: 206-616-4853, 543-6442
Fax: 206-543-8673
E-mail: xingde@u.washington.edu
Research Description
Our major research interest centers on developing optically-based, non-invasive imaging and spectroscopic techniques and their applications in biomedicine. Our mission is to develop translational biophotonic technologies that interface or bridge the basic engineering research and medical diagnosis. The research involves integration of multi-disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. Applications of the technologies include detection of diseases at early, manageable stages; monitoring therapeutic effects and treatment outcomes; and guiding excisional biopsy and interventions.
Exemplary technological/engineering projects:
- Development of a new-generation, MEMS-based, miniature optical imaging probe (endoscope/catheter), which is multimodal and functionally switchable between complementary optical imaging techniques including optical coherence tomography, confocal and multi-photon fluorescence imaging;
- Development of an ultrahigh-resolution optical coherence tomography (OCT) system for structural and functional interrogation of biological tissues in vivo in a non-invasive fashion (on human subjects and animal models);
- Development of novel bio-functionalizable nano contrast agents of various shapes and structures for molecular imaging. The nano probes can also be potentially used for targeted therapy;
- Development and implementation of fast data processing methods/algorithms for extracting structural, spectroscopic and functional diagnostic information in real time;
- Development of a highly sensitive real-time fluorescence detection system/method for molecular imaging and/or cell tracking.
Exemplary biomedical applications of the translational technologies include:
- Assessing natural or stimulated wound healing or tissue regeneration under various physiological (and/or pathological) conditions;
- Early detection of (epithelial) neoplasia (such as in the GI tract, etc);
- Exploring and evaluating early neoplastic signatures for optical imaging/spectroscopy during tumorigenesis;
- Non-destructive evaluation of materials and micro devices using optical imaging and spectroscopic techniques.
Teaching Activities
Honors and Awards
- 2002: Distinguished Teacher/Mentor Award, Dept of Bioengineering, University of Washington
- 2004: NSF Career Development Award
Selected Publications
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- M. J. Cobb, Y. C. Chen, R. Underwood, R. Thariani, M. Usui, J. E. Olerud, and X. D. Li, “Non-invasive assessment of cutaneous wound healing using high-resolution optical coherence tomography,” Journal of Biomedical Optics, in press (2006).
- M. J. Cobb, Y. C. Chen, S. Baily, C. Kemp, and X. D. Li, “Non-invasive detection of early neoplasia in carcinogen-induced skin cancer mouse models in vivo,” Cancer Biomarkers 2(3-4):163-173 (2006).
- H. W. Ren, and X. D. Li, "Clutter rejection filters for optical Doppler tomography," Optics Express, 14(13):6103-6112 (2006).
- M. T. Myaing, D. J. MacDonald, and X. D. Li, "Fiber-optic scanning two-photon fluorescence endoscope," Optics Letters 31(8):1076-1079 (2006).
- H. W. Ren, T. Sun, D. J. MacDonald, M. J. Cobb, and X. D. Li, "Real-time in vivo blood flow imaging by moving scatterer sensitive spectral domain optical Doppler tomography," Optics Letters 31(7):927-929 (2006).
- H. Cang, T. Sun, Z. Y. Li, J. Chen, B. J. Wiley, Y. N. Xia, and X. D. Li, "Gold nanocages as potential contrast agents for spectroscopic optical coherence tomography," Optics Letters 30(22):3048-3050 (2005).
- Y. C. Chen, X. M. Liu, M. J. Cobb, M. T. Myaing, T. Sun, and X. D. Li, "Optimization of optical spectral throughput of acousto-optic modulators for high-speed optical coherence tomography," Optics Express 13(20):7816-7822 (2005).
- J. Y. Chen, B. Wiley, Z. Y. Li, D. Campbell, F. Saeki, H. Cang, L. Au, J. Lee, X. D. Li, and Y. N. Xia, "Gold nanocages: Engineering their structure for biomedical applications," Advanced Materials 17( 18):2255-2261 (2005).
- M. J. Cobb, X. M. Liu, and X. D. Li, "Continuous focus tracking for real-time optical coherence tomography," Optics Letters 30(13):1680-1682 (2005).
- J. Y. Chen, F. Saeki, B. J. Wiley, H. Cang, J. M. Cobb, Z. Y. Li, L. Au, H. Zhang, M. B. Kimmey, X. D. Li, and Y. N. Xia, "Bioconjugated gold nanocages and evaluation of their potential for optical imaging and thermal therapeutic applications," Nano Letters 5(3): 473-477 (2005).
- J. H. Hwang, M. J. Cobb, M. B. Kimmey, and X. D. Li, "Optical coherence tomography imaging of the pancreas: a needle-based approach," Clinical Gastroenterology and Hepatology 3(7 Suppl 1):S49-52 (2005).
- Y. C. Chen, and X. D. Li, "Dispersion management for real-time optical coherence tomography involving a phase modulator," Optics Express 12 (24):5968-5978 (2004).
- X. M. Liu, Y. C. Chen, M. J. Cobb, M. B. Kimmey, and X. D. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Optics Letters 29(15):1763-1765 (2004).
- X. M. Liu , M.J. Cobb, and X.D. Li, “Rapid Scanning All-reflective Optical Line for Real-time Optical Coherence Tomography, Optics Letters 29(1):80-82 (2004).
Book Chapter
- X. D. Li, and J. G. Fujimoto, “Optical Coherence Tomography,” in Encyclopedia of Biomaterials and Biomedical Engineering, Gary E. Wnek and Gary L. Bowlin, Eds., Marcel Dekker, Inc., New York, 2004.
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