Daniel Chiu

Joint A. Bruce Montgomery Professor of Chemistry, Professor of Bioengineering

Phone: (206)543-1655
Office: Bagley 204


Lab Website

How I am inventing the future of medicine

I am developing new technologies to address pressing needs in biomedicine.
Research Interests

Advance optical instrumentation
Single-molecule studies
Single-cell biology
Oncology; Synaptic Function
Research Description

My lab is focused on developing new methods for probing complex biological processes at the single-cell and single-molecule level, and on applying these new techniques for addressing pressing biological problems.

Ph.D in Chemistry, Stanford University, 1998
B.A. in Neurobiology, B.S. in Chemistry, University of California at Berkeley, 1993
Postdoc Information

Postdoctoral Fellow, Harvard University, 2000
Awards and Honors

2012 Elected AAAS Fellow
2011 UW Presidential Entrepreneurial Faculty Fellow
2010 Analytical Chemistry Young Innovator Award
2009 Pittcon Achievement Award
2007 American Chemical Society National Fresenius Award
2005 Alfred P. Sloan Fellow
2004 McKnight Technological Innovations in Neuroscience Award
2003 Keck Distinguished Young Scholar in Biomedical Research
2002 NIH Cutting-Edge Technology in Basic Research Award
2002 National Science Foundation Career Award
2000 Research Corporation’s Research Innovation Award
2000 Dreyfus New Faculty Award
UW Bioengineering Courses Taught

Selected Publications

T. Schneider, J. Kreutz, D.T. Chiu (2013) “The potential impact of droplet microfluidics in biology” Anal. Chem. 85, 3476-3482.

S.A. Mutch, P. Kensel-Hammes, J.C. Gadd, B.S. Fujimoto, R.W. Allen, P.G. Schiro, R.M. Lorenz, C.L. Kuyper, J.S. Kuo, S.M. Bajjalieh, D.T. Chiu (2011) “A quantitative single vesicle imaging technique reveals a subset of synaptic vesicle membrane proteins are trafficked with high precision” J. Neurosci. 31, 1461-1470.

S.A. Mutch, B. Fujimoto, C.L. Kuyper, J.S. Kuo, S.M. Bajjalieh, D.T. Chiu (2007) “De-convolving single-molecule intensity distributions for quantitative microscopy measurements” Biophys. J. 92, 1-18.

Y. Zhao, J.S. Edgar, G.D.M. Jeffries, D. McGloin, D.T. Chiu (2007) “Spin-to-orbital angular momentum conversion in a strongly focused optical beam” Phys. Rev. Lett. 99, 073901.

P.G. Schiro, M. Zhao, J.S. Kuo, T. Schneider, K.M. Koehler, D.E. Sabath, D.T. Chiu (2012) “Sensitive and high-throughput isolation of rare cells from peripheral blood with ensemble decision aliquot ranking” Angew. Chem. Int. Ed. 51, 4618-4622.

M. He, J.S. Edgar, G.D.M. Jeffries, R.M. Lorenz, J.P. Shelby, D.T. Chiu (2005) “Selective encapsulation of single cells and subcellular organelles into picoliter and femtoliter-volume droplets” Anal. Chem. 77, 1539–1544.

K.A.D. Gregersen, Z.B. Hill, J.C. Gadd, B.S. Fujimoto, D.J. Maly, D.T. Chiu (2010) “Intracellular Delivery of Bioactive Molecules using Light-Addressable Nanocapsules” ACS Nano 4, 7603-7611.

J.S. Edgar, G. Milne, Y. Zhao, C.P. Pabbati, D.S.W. Lim, D.T. Chiu (2009) ”Droplet compartmentalization of chemical separations” Angew. Chem. Int. Ed. 48, 2719-2722.

J.P. Shelby, J. White, K. Ganesan, P.K. Rathod, D.T. Chiu (2003) “A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes” Proc. Natl. Acad. Sci. U.S.A. 100, 14618–14622.

J. P. Shelby, D.S.W. Lim, J.S. Kuo, D.T. Chiu (2003) “Generation of ultra-high radial accelerations in microvortices” Nature 425, 38.

G.D.M. Jeffries, J.S. Kuo, D.T. Chiu (2007) “Dynamic modulation of chemical concentration in an aqueous droplet” Angew. Chem. Int. Ed. 46, 1326-1328.

G.D.M. Jeffries, J.S. Edgar, Y. Zhao, J.P. Shelby, C. Fong, D.T. Chiu (2007) “Using polarization-shaped optical vortex traps for single cell nanosurgery” Nano Lett. 7, 415-420.

F. Ye, C. Wu, Y. Jin, Y.H. Chan, X. Zhang, D.T. Chiu (2011) “Ratiometric temperature sensing with semiconducting polymer dots” J. Amer. Chem. Soc. 133, 8146-8149.

D.T. Chiu & R.M. Lorenz (2009) “Chemistry and biology in femtoliter and picoliter volume droplets” Accounts of Chem. Res. 42, 649-658.

D.E. Cohen, T. Schneider, M. Wang, D.T. Chiu (2010) “Self-digitization of sample volumes” Anal. Chem. 82, 5707-5717.

C. Wu, Y. Jin, T. Schneider, D. Burnham, and D.T. Chiu (2010) “Ultra-bright and bio-orthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry” Angew. Chem. Int. Ed. 49, 9436-9440.

C. Wu, T. Schneider, M. Zeigler, J. Yu, P.G. Schiro, D.R. Burnham, J.D. McNeill, D.T. Chiu (2010) “Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting” J. Amer. Chem. Soc. 132, 15410-15417.

C. Wu, S.J. Hansen, Q. Hou, J. Yu, M. Zeigler, Y. Jin, D.R. Burnham, J.D. McNeill, J.M. Olson, D.T. Chiu (2011) “Design of highly emissive polymer blend bioconjugates for in vivo tumor targeting” Angew. Chem. Int. Ed. 50, 3430-3434.

C. Wu and D.T. Chiu (2013) “Semiconducting polymer dots: A new family of fluorescent nanoparticles for biological applications” Angew. Chem. Int. Ed. 52, 3086-3109.

B. Sun and D. T. Chiu (2003) “Spatially and temporally resolved delivery of stimuli to single cells” J. Am. Chem. Soc. 125, 3702–3703.


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