Anthony Convertine

Research Assistant Professor

aconv@u.washington.edu
Phone: (206)221-5113
Office: Foege N510E


UW Bioengineering faculty Anthony Convertine

Lab Website
How I am inventing the future of medicine
Research Interests
Research Description
The efficient intracellular delivery of therapeutic biomacromolecules such as nucleic acids, peptides, and proteins to intracellular compartments remains a significant obstacle to the biopharmaceutical world. In order to exert their therapeutic affect these drugs, must overcome a wide range of systemic and intracellular barriers before reaching the cytoplasm. Because of the difficulty of achieving intracellular delivery current proteins and peptide therapeutics exclusively target extracellular receptors. The development of versatile new drug delivery technologies specifically tailored to the needs of biomacromolecular drugs could lay the foundation for an entire new class of biologic drugs. Recent advances from the nanotechnology and polymer chemistry fields have created the opportunity to develop these transformative delivery capabilities.
Education
PhD, Polymer Science and Engineering, University of Southern Mississippi, 2011
BS, Polymer Science, University of Southern Mississippi, 2006

Postdoc Information
Awards and Honors
UW Bioengineering Courses Taught
Selected Publications
Lundy BB, A ConverGne A, Miteva M, Stayton PS Neutral Polymeric Micelles for RNA Delivery Bioconjugate chemistry. ASAP Featured cover arFcle for March 2013

Schellinger JG, Pahang JA, Johnson RN, Chu DSH, Sellers DL, Maris DO, ConverGne AJ, Stayton PS, Horner PJ Pun SH Meli`n-­‐grahed HPMA-­‐oligolysine based copolymers for gene delivery Biomaterials 2013 34, 9, 2013, 2318–2326.

Berguig GY, ConverGne AJ, Shi J, Palanca-­‐Wessels MC, Duvall CL, PunSH, Press OW, Stayton PS Intracellular Delivery and Trafficking Dynamics of a Lymphoma-­‐TargeGng AnGbody–Polymer Conjugate Molecular pharmaceuGcs 2012 9, 12, 3506-­‐3514.

Cheng C, ConverGne AJ, Stayton PS, Bryers JD MulGfuncGonal triblock copolymers for intracellular messenger RNA delivery Biomaterials 2012 33, 28, 6868–6876.

Chu DSH, Schellinger JG Shi J, ConverGne AJ, Stayton PS, Pun SH. ApplicaGon of Living Free Radical PolymerizaGon for Nucleic Acid Delivery Accounts of chemical research 2012 ASAP DOI:10.1021/ar200242z

Manganiello, MJ, Cheng C, ConverGne AJ, Bryers, JD, Stayton, PS. Diblock copolymers with tunable pH transiGons for gene delivery Biomaterials 2012;33(7):2301-­‐2309. Language: English, DOI:10.1016/j.biomaterials.2011.11.019

Palanca-­‐Wessels MC, ConverGne AJ, Cutler-­‐Strom R, Booth GC, Lee F, Berguig GY, Stayton, PS, Press OW AnG-­‐CD22 AnGbody TargeGng of pH-­‐responsive Micelles Enhances Small Interfering RNA Delivery and Gene Silencing in Lymphoma Cells Molecular Therapy 2011;19(8):
1529-­‐1537. DOI:10.1038/mt.2011.104 PubMed PMID: 21629223; PubMed Central PMCID: PMC3149160

Crownover EF, ConverGne AJ, Stayton PS, pH-­‐responsive polymer-­‐anGgen vaccine bioconjugates Polymer Chemistry 2011;2(7):1499-­‐1504. DOI:10.1039/c1py00060h

Crownover E, Duvall, CL, ConverGne AJ, Hoffman AS, Stayton PS RAFT-­‐synthesized grah copolymers that enhance pH-­‐dependent membrane destabilizaGon and protein circulaGon Gmes Journal of Controlled Release 2011;155(2), 167-­‐174. DOI:10.1016/j.jconrel.2011.06.013
PubMed PMID: 21699931; PubMed Central PMCID: PMC3273495

Duvall, CL, ConverGne AJ, Benoit DSW, Hoffman AS, Stayton PS Intracellular Delivery of a ProapoptoGc PepGde via ConjugaGon to a RAFT Synthesized EndosomolyGc Polymer Molecular PharmaceuGcs 2010;7(2): 468-­‐476. DOI:10.1021/mp9002267 PubMed PMID: 19968323; PubMed Central PMCID: PMC2849913

 

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