Lawrence Crum

Research Professor

lac@apl.washington.edu
Phone: (206)685-8622
Office: OOB 208

UW Bioengineering faculty Lawrence Crum

Lab Website
How I am inventing the future of medicine
Medical Imaging
Physical acoustics
Industrial acoustics
Sonoluminescence
Research Interests
Global health
In vitro diagnostic assays
Stimuli-responsive polymers
Nanomaterials
Protein conjugates
Biomolecule separation
Research Description
Acoustic Hemostasis
the use of High Intensity Focused Ultrasound (HIFU) to stop bleeding
Image-guided HIFU Therapy
the use of ultrasound-guidance to generate HIFU lesions in vivo
Extracorporeal Shock Wave Lithotripsy
the use of acoustic shock waves to comminute kidney stones
Ultrasound-Enhanced Drug Delivery
the use of ultrasound to accelerate the transport of drugs, in both intra-vascular and transdermal applications
The Physics of Ultrasound Contrast Agents
the use of stabilized microbubbles to enhance echogenicity in diagnostic ultrasound devices
Single Bubble Sonoluminescence
the study of how ultrasound can generate light
Sonochemistry and Toxic Waste Remediation
Education
PhD (physics), University of Ohio, 1967
MS (physics), University of Ohio, 1965
BS (mathematics), University of Ohio, 1963
Postdoc Information
Awards and Honors
2002, Honorary Visiting Professor, Moscow State University
2002, Honorary Visiting Professor, Chongqing Medical University
2000, Helmholtz-Rayleigh Medal, Acoustical Society of America
1999, Honorary Doctorate, University of Brussels
1998, President, Acoustical Society of America
UW Bioengineering Courses Taught
Selected Publications
Therapeutic Ultrasound, Proceedings of the 2nd International Symposium, M.A. Andrew, L.A. Crum and S. Vaezy, eds (American Institute of Physics Press), 2003.

Image-guided acoustic hemostasis, L. A. Crum, M. R. Bailey, Carter S, Curra F, Kaczkowski P, Kargl S, In: “New Acoustics: Selected Topics,” C. Ranz-Guerra and J. A. Gallego-Juarez, eds., (Consejo Superior de Investigaciones Cientificas, Madrid), pp 26-36 (2002).

Sonochemistry and Sonoluminescence, L. Crum, T. Mason, J. Reisse, and K. Suslick, eds., NATO ASI Series, Vol. 524 (Kluwer Academic Publishers: Dordrecht), 1999.

The Sound of the Future: A Global View of Acoustics in the 21st Century, (Proceedings of the 16th International Congress on Acoustics and the 135th meeting of the Acoustical Society of America), P. K. Kuhl and L. A. Crum, eds., (American Institute of Physics: New York), 1998, pp. 3042.

Shocking Revelations, L. A. Crum and T. J. Matula, Science, 276, 1348-1349 (1997).

Hemostasis using High Intensity Focused Ultrasound, S. Vaezy, R. Martin, P. Mourad, and L. A. Crum, European J. of Ultrasound, 9, 79-87 (1999).

Evidence for gas exchange in single bubble sonoluminescence, T. J. Matula and L. A. Crum, Phys. Rev. Letts. 80, 865-868 (1998).

Bubbles hotter than the sun, L. A. Crum, New Scientist, 146, 36-41 (1995).

Liver hemostasis using high intensity focused ultrasound, S. Vaezy, R. Martin, U. Schmiedl, M. Caps, S. Taylor, K. Beach, S. Carter, P. Kaczkowski, G. Keilman, S. Helton, W. Chandler, P. Mourad, M. Rice, R. Roy, and L. Crum, Ultrasound in Med. and Biol. 23, 1413-1420 (1997).

Therapeutic ultrasound: Surgery and drug delivery, F. P. Curra, and L. A. Crum, Acoustical Science and Technology, 24 (6), 343-348 (2003).

Pulsed high-intensity focused ultrasound-induced endothelial cell injury in vessels infused with ultrasound contrast agent, Hwang JH, A. A. Brayman, and S. Vaezy, In M. A. Andrew, L. A. Crum, and S. Vaezy, eds, Proc 2nd International Symp on Therapeutic Ultrasound, Seattle, WA, 63-71 (2003).

High-intensity focused ultrasound: A potential new treatment for gastrointestinal bleeding, J. H. Hwang, S. Vaezy, R. W. Martin, M. Y. Cho, M. L. Noble, L. A. Crum, and M. B. Kimmey, Gastrointestinal Endoscopy, 58, 111-115 (2003).

Cavitation bubble cluster activity in the breakage of kidney stones by lithotripter shock waves, Y. A. Pishchalnikov, O. A. Sapozhnikov, J. C. Williams, A. P. Evan, J. A. McAteer, R. O. Cleveland, T. Colonius, M. R. Bailey, and L. A. Crum, J Endourology, 17 (7), 435-446 (2003).

 

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