Research Associate Professor
Office: MolES 226
Mass Spectral Imaging
My newer research involves the development of techniques for improved analysis of the biomolecule-surface interfaces (for example nanoparticles) as well as improved chemical imaging of biologically relevant samples. Imaging secondary ion mass spectrometry is a surface characterization technique that can provide molecular information with sub-micron resolution. Utilizing the newer cluster ion sources allows us to get 3-D images of cells and tissues as well. The ability to get sub-cellular images of cell and tissues with chemical and molecular specificity would open up a range of possibilities for better understanding and diagnosing biological processes such as tumor microenvironments, lipid metabolomics relationship to cancer, tissue repair, and chemical analysis of tissue and/or cells on a cellular and sub-cellular level. My research involves development of the sample preparation, technique development, data processing, and data analysis is critical to make this technology more applicable to the biological/medical community.
BA, University of California, Santa Cruz
Senior Scientist, Space Dynamics Laboratory
Archana N. Rao, Nicolas Vandencasteele, Lara J. Gamble, and David W. Grainger, “High-Resolution Epifluorescence and Time-of-Flight Secondary Ion Mass Spectrometry Chemical Imaging Comparisons of Single DNA Microarray Spots”, Analytical Chemistry 2012 84 (24), 10628-10636. DOI: 10.1021/ac3019334
C.-Y. Lee, P. Gong, G.M. Harbers, D.W. Grainger, D.G. Castner, and L.J. Gamble, “Surface Coverage and Structure of Mixed DNA/Alkylthiol Monolayers on Gold: Characterization by XPS, NEXAFS, and Fluorescence Intensity Measurements”, Anal. Chem., 78, p3316-3325, 2006.
P. Gong, C.-Y. Lee, L.J. Gamble, D.G. Castner, and D.W. Grainger, “Hybridization Behavior of Mixed DNA/Alkylthiol Monolayers on Gold: Characterization by Surface Plasmon Resonance and 32P Radiometric Assay”, Anal. Chem., 78, p3326-3334, 2006