Matthew O’Donnell

Professor

odonnel@uw.edu
Phone: (206)465-2144
Office: Benjamin Hall Bldg. 514

odonnell-cropped

Lab Website

How I am inventing the future of medicine

I am developing molecular imaging and integrated molecular theranostic systems based on photoacoustics and ultrasound technologies to translate the promise of molecular medicine into a clinical reality.
Research Interests

Biomedical imaging
Photoacoustics
Ultrasonics
Molecular contrast agents
Research Description

My lab is developing molecular agents and systems for photoacoustic and ultrasonic molecular imaging. Also, we look at integrated therapeutics for molecular-level theransotics (i.e., integrated diangostics and therapy).
Education

PhD, Solid State Physics, University of Notre Dame, 1972-1976
BS, Physics, University of Notre Dame, 1968-1972
Postdoc Information

Physicist, Research and Development Center, General Electric Company, Schenectady, NY 12301,1980-1990.
Research Fellow, Electrical Engineering, Yale University, New Haven, CT, 1984-1985.
Senior Research Associate in Physics and Research Instructor in Medicine, Washington University, St. Louis, MO 63130, 1978-1980.
Postdoctoral Fellow in Physics, Washington University, St. Louis, MO 63130, 1976- 1978.
Awards and Honors

Distinguished Alumni Award, University of Notre Dame, 2009
National Academy of Engineering, 2009
Washington State Academy of Sciences, 2009
Achievement Award, IEEE Ultrasonics, Ferroelectrics & Frequency Control Society, 2007
Frank & Julie Jungers Dean of Engineering, University of Washington, 2006
Jerry W. and Carol L. Levin Professor of Engineering, University of Michigan, 1998
Research Award, BME Department, University of Michigan, 1998
Fellow – AIMBE, 1996
Teaching Award, College of Engineering, University of Michigan, 1996
Teaching Award, EECS Department, University of Michigan, 1995
Fellow – IEEE, 1993
Whitney Award, General Electric Internal Research Award, May 1991
Whitney Award, General Electric Internal Research Award, November 1990
Best Paper – Medical Physics, 1985
Best Paper – Medical Physics, 1984
Senior Member – IEEE, 1984
B.S. with Honors – University of Notre Dame, 1972
UW Bioengineering Courses Taught

BIOEN 504: Introduction to Technology Commercialization
Selected Publications

T-M Nguyen, S. Song, B. Arnal, E.Y. Wong, Z. Huang, R.K. Wang, and M. O’Donnell, “Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography,” Journal of Biomedical Optics 19(1), 016013 (2014).

C-W Wei, M. Lombardo, K. Larson-Smith, I.M. Pelivanov, C. Perez, J. Xia, T.J. Matula, D. Pozzo, and M. O’Donnell, “Nonlinear contrast enhancement in photoacoustic molecular imaging with gold nanosphere encapsulated nanoemulsions,” Phys. Lett. 104, 033701 (2014).

T-M Nguyen, S. Song, B. Arnal, Z. Huang, M. O’Donnell, and R. K. Wang, “Visualizing ultrasonically-induced shear wave propagation using phase-sensitive optical coherence tomography for dynamic elastography,” Optics Letters 39(4), pp. 838–841 (2014).

Pelivanov, T. Buma, J. Xia, C.-W. Wei, and M. O’Donnell, ” NDT of fiber-reinforced composites with a new fiber-optic pump-probe laser-ultrasound system,” Photoacoustics 2(2), pp. 63-74 (2014).

Pelivanov, T. Buma, J. Xia, C.-W. Wei, and M. O’Donnell, ” A new fiber-optic non-contact compact laser-ultrasound scanner for fast NDT&E of aircraft composites,” Journal of Applied Physics 115, 113105 (2014).

C-W Wei, J. Xia, M. Lombardo, C. Perez, B. Arnal, K. Larson-Smith, I.M. Pelivanov, T.J. Matula, D. Pozzo, and M. O’Donnell, “Laser-induced cavitation in nanoemulsion with gold nanospheres for potential therapeutic applications,” Optics Letters 39(9), pp. 2599-2602 (2014).

B. Compas, E.Y. Wong, X. Huang, S. Sampath, B.A. Lin, P. Pal, X. Papademetris, K. Thiele, D. P. Dione, L. H. Staib, A. J. Sinusas, M. O’Donnell, and James S. Duncan, “Radial Basis Functions for Combining Shape and Speckle Tracking in 4D Echocardiography,” IEEE Transactions on Medical Imaging 33(6), pp. 1275-1289 (2014).

Li, T. Khokhlova, O. Sapozhnikov, M. O’Donnell, and J.H. Hwang, “A New Active Cavitation Mapping Technique for Pulsed HIFU Applications – Bubble Doppler,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 61, no. 10, pp. 1698-1708 (2014).

Arnal, T-M Nguyen, and M. O’Donnell, “Toric Focusing for Radiation Force Applications using a Toric Lens Coupled to a Spherically Focused Transducer,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 61, no. 12, pp. 2032-2041 (2014).

C-W Wei, T-M Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. Pelivanov, M. O’Donnell, “Real-time Integrated Ultrasound and Photoacoustic Imaging System,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 62, no. 2, pp. 319-328 (2015).

J-W Li, B. Arnal, C-W Wei, J. Shang, M. O’Donnell, and X. Gao, “Magneto-optical Nanoparticles for Cyclic Magnetomotive Photoacoustic Imaging,” ACS Nano 9(2), pp. 1964-1976 (2015).

T-M Nguyen, B. Arnal, S. Song, Z. Huang, R. K. Wang, and M. O’Donnell, “Shear Wave Elastography Using Amplitude Modulated Acoustic Radiation Force and Phase-sensitive Optical Coherence Tomography,” Journal of Biomedical Optics 20(1), 016001 (2015).

Arnal, C. Perez, C-W Wei,  J. Xia, M. Lombardo, I. Pelivanov, T. J. Matula, L. D. Pozzo, and M. O’Donnell, “Sono-photoacoustic Imaging of Gold Nanoemulsions: Part I. Exposure Thresholds,” Photoacoustics 3(1), pp. 3-10 (2015).

Arnal, C-W Wei,  C. Perez, T-M Nguyen, M. Lombardo, I. Pelivanov, L. D. Pozzo, and M. O’Donnell, “Sono-photoacoustic Imaging of Gold Nanoemulsions: Part II. Real-time Imaging,” Photoacoustics 3(1), pp. 11-19 (2014) (2015).

 

In the News