Matthew O’Donnell

Phone: (206)465-2144
Office: Benjamin Hall Bldg. 514


Lab Website

How I am inventing the future of medicine

I am developing molecular imaging and integrated molecular theranostic systems based on photoacoustics and ultrasound technologies to translate the promise of molecular medicine into a clinical reality.
Research Interests

Biomedical imaging
Molecular contrast agents
Research Description

My lab is developing molecular agents and systems for photoacoustic and ultrasonic molecular imaging. Also, we look at integrated therapeutics for molecular-level theransotics (i.e., integrated diangostics and therapy).

PhD, Solid State Physics, University of Notre Dame, 1972-1976
BS, Physics, University of Notre Dame, 1968-1972
Postdoc Information

Physicist, Research and Development Center, General Electric Company, Schenectady, NY 12301,1980-1990.
Research Fellow, Electrical Engineering, Yale University, New Haven, CT, 1984-1985.
Senior Research Associate in Physics and Research Instructor in Medicine, Washington University, St. Louis, MO 63130, 1978-1980.
Postdoctoral Fellow in Physics, Washington University, St. Louis, MO 63130, 1976- 1978.
Awards and Honors

Distinguished Alumni Award, University of Notre Dame, 2009
National Academy of Engineering, 2009
Washington State Academy of Sciences, 2009
Achievement Award, IEEE Ultrasonics, Ferroelectrics & Frequency Control Society, 2007
Frank & Julie Jungers Dean of Engineering, University of Washington, 2006
Jerry W. and Carol L. Levin Professor of Engineering, University of Michigan, 1998
Research Award, BME Department, University of Michigan, 1998
Fellow – AIMBE, 1996
Teaching Award, College of Engineering, University of Michigan, 1996
Teaching Award, EECS Department, University of Michigan, 1995
Fellow – IEEE, 1993
Whitney Award, General Electric Internal Research Award, May 1991
Whitney Award, General Electric Internal Research Award, November 1990
Best Paper – Medical Physics, 1985
Best Paper – Medical Physics, 1984
Senior Member – IEEE, 1984
B.S. with Honors – University of Notre Dame, 1972
UW Bioengineering Courses Taught

BIOEN 504: Introduction to Technology Commercialization
Selected Publications

M. O’Donnell, C.W. Wei, J. Xia, I. Pelivanov, C. Jia, S-W Huang, X. Hu, amd X. Gao, “Can Molecular Imaging Enable Personalized Diagnostics? An Example using Magnetomotive Photoacoustic Imaging,” Annals of Biomedical Engineering 41(11), pp. 2237-47 (2013) (invited paper).

C.W. Wei, J. Xia, I. Pelivanov, C. Jia, S-W Huang, X. Hu, X. Gao, and M. O’Donnell, “Magnetomotive Photoacoustic Imaging,” Journal of Biophotonics 6(6-7), pp. 513-522 (2013).

X. Hu, C.W. Wei, J. Xia, I. Pelivanov, M. O’Donnell, and X. Gao “Trapping and Photoacoustic Detection of CTCs at Single Cell/mL Level with Magneto-Optical Coupled Nanoparticles,” Small 9(12), pp. 2046-2052 (2013).

M. O’Donnell, C.W. Wei, J. Xia, I. Pelivanov, X. Gao, X. Hu, “Detecting Circulating Tumor Cells with Integrated Photoacoustic/Ultrasonic Imaging,” OSA Optics and Photonics 2012: Biomedical Optics (Biomed), BM2B.1 (2012) (Invited paper).

J. Xia, I. Pelivanov, C.W. Wei, X. Hu, X. Gao, and M. O’Donnell, “Suppression of Background Signal in Magneto-motive Photoacoustic Imaging of Magnetic Contrast Agents Targeting Cancer Cells,” J. Biomed. Opt. Vol. 17(6), 061224 (2012).

M. O’Donnell, “Coupled Contrast for Photoacoustic Imaging and Detection,” presented at the 161st Meeting of the Acoustical Society of America, J. Acoust. Soc. Am. 129(4), p. 2641 (2011) (invited paper).

M. O’Donnell, “Magnetomotive Photoacoustic (mmPA) Imaging to Suppress Background Signals in Molecular Imaging,” presented at the 12th ECI Conference on Advances in Optics for Biotechnology, Medicine, and Surgery, p. 24 (2011) (invited paper).

M. O’Donnell and X. Gao, “Developments in Ultrasonic and Photoacoustic Imaging Technology,” presented at the 3rd Frontiers in Biomedical Imaging Conference at Vanderbilt University, p. 18 (2011) (invited paper).

B. A. Lin, C. B. Compas, S. Sampath, Z. Zhang, D. P. Dione, Q. Wei, K. Thiele, M. O’Donnell, J. S. Duncan, and A. J. Sinusas, “Development and validation of integrated shape and rf-based speckle tracking for evaluation of regional myocardial deformation,” Journal of the American Society of Echocardiography 24:B23–B24 (2011). (American Society of Echocardiography 22nd Annual Scientific Sessions).

Y. Jin, C. Jia, S-W Huang, M. O’Donnell, and X. Gao, “Multifunctional Nanoparticles as Coupled Contrast Agents,” Nature Communications 1:41 (doi:10.1038/ncomms1042), 8 pages (July, 2010).


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