Project Description

Robert F. Rushmer Professor

spun@u.washington.edu
Phone: (206)685-3488
Office: Foege N530P


UW Bioengineering faculty Suzie Pun

We are developing new materials to improve and/or enable delivery of macromolecule drugs.
Biomaterials
Drug delivery
Cancer
CNS disorders
Hemostatic polymers
Renal disease treatment

The overarching goal of our research is to develop bio-inspired materials for medical applications. Our general approach is to mimic pathways used by nature in our materials design. To this end, we have identified bioactive peptide and aptamer motifs through library selection. Using these motifs, we synthesize highly uniform and scalable materials with controlled compositions, structures and sizes that can be used for versatile biomedical applications. The Pun group focuses on door-opening technologies in drug delivery, including innovations for macromolecule delivery to the central nervous system, development of injectable hemostatic polymers, technologies for drug delivery to the kidney and materials for controlled modulation of the immune system for cancer treatment.

PhD Chemical Engineering California Institute of Technology, 2000
MS Chemical Engineering, California Institute of Technology
BS Chemical Engineering, Stanford University

2015 AAAS-Lemelson Invention Ambassador
2015 National Academy of Inventors Fellow
2015 American Institute for Medical and Biological Engineering (AIMBE) College of Fellows
2014 Controlled Release Society Young Investigator Award
2014 Inaugural Biomaterials Science Lectureship
2008 Undergraduate Mentor Award, University of Washington
2008 Junior Faculty Innovator Award, UW College of Engineering
2007 Outstanding Teacher/Mentor Award, UW Bioengineering
2006 Presidential Early Career Award for Scientists and Engineers (PECASE)
2005 National Science Foundation CAREER Award
2005 Alliance for Cancer Gene Therapy Young Investigator Award
2002 MIT Technology Review’s TR100 Award: “top 100 young innovators”
2000 Everhart Lectureship Prize, California Institute of Technology

Bioen 345: Failure Analysis of Physiologic Systems
Bioen 491: Controlled Release Systems
Bioen 494/Bioen 594: Advanced Drug Delivery

Sellers, D.L., Bergen, J.M., Johnson, R.N., Ravits, J., Horner, P.H., and Pun, S.H. (2016) Targeted Axonal Import (TAxI) peptide delivers functional proteins into the spinal cord after peripheral administration.  PNAS, v113:2514-2519.

Cheng, Y., Wei, H., Tan, J.K., Peeler, D.J., Maris, D.O., Sellers, D.L., Horner, P.J. and Pun, S.H.  Nano-sized sunflower polycations as effective gene transfer vehicles. Small, v12:2750-2758.

Ngambenjawong, C., Gustafson, H.H., Pineda, J.M., Cieslewicz, M.E., Pun, S.H. (2016) Serum stability and affinity optimization of an M2 macrophage-targeting peptide (M2pep). Theranostics, v6(9):1403-1414.

Chan, L.W-G., Wang, X., Wei, H., Pozzo, L.D., White, N.J., and Pun, S.H. (2015) Fibrin-crosslinking polymers for modulating clot properties and inducing hemostasis. Sci Trans Med, v7(277):277ra29

Sellers, D.L., Kim, T.H., Mount, C.W., Pun, S.H., and Horner, P.J. (2014) Prolonged hirudin delivery from poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 and functional recovery from a demyelination lesion.  Biomaterials, v35:8895-8902.

Cieslewicz, M.E., Tang, J.J., Yu, J., Cao, H., Zavaljevski, M., Lieber, A., Raines, E.W., and Pun, S.H.  (2013) Targeted delivery of pro-apoptotic peptides to tumor-associated macrophages improves survival.  PNAS, v110:15919-15924.

Wei, H., Volpatti, L.R.,  Sellers, D.L., Maris, D.O., Andrews, I.W., Hemphill, A.S., Chan, L.W., Chu, D.S.H., Horner, P.J., and Pun, S.H. (2013) Dual-responsive, stabilized nanoparticles for efficient in vivo plasmid delivery.  Angewandte Chemie, v52:5377-5381

Shi, J., Chou, B., Choi, J.L., Johnson, R.N., Schellinger, J.G., and Pun, S.H.  (2013) Effect of polyplex morphology on cellular uptake, intracellular trafficking and transgene expression.  ACS Nano, v7:10612-10620.

*Wei, H., *Chu, D.S..H., Zhao, J.,Pahang, J., and Pun, S.H. (2013) Synthesis and evaluation of cyclic cationic polymers for gene delivery.  ACS Macro Lett, v2:1047-1050.

Wei, H., Schellinger, J.G., Chu, D.S.H., and Pun, S.H. (2012) Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. JACS, v134:16554-16557.

 

In the News

  • Drug capture system

UW, Academia Sinica researchers develop “drug capture system” to treat limb ischemia

December 6th, 2016|Comments Off on UW, Academia Sinica researchers develop “drug capture system” to treat limb ischemia

  • Vials in a laboratory

Pun lab researchers win national cancer treatment nanotech challenge

September 20th, 2016|Comments Off on Pun lab researchers win national cancer treatment nanotech challenge

  • Illustration of human eye

UW Bioengineering student-run journal Denatured debuts

July 28th, 2016|Comments Off on UW Bioengineering student-run journal Denatured debuts

  • A micrograph of a motor neuron cell showing its extended fibers.

TAxI peptide shuttles protein cargo into spinal cord

February 17th, 2016|Comments Off on TAxI peptide shuttles protein cargo into spinal cord

  • Suzie Pun, Professor of Bioengineering

Suzie Pun named 2015 National Academy of Inventors Fellow

December 22nd, 2015|Comments Off on Suzie Pun named 2015 National Academy of Inventors Fellow

  • Suzie Pun, Professor of Bioengineering

Suzie Pun selected as 2015-16 AAAS-Lemelson Invention Ambassador

July 29th, 2015|Comments Off on Suzie Pun selected as 2015-16 AAAS-Lemelson Invention Ambassador