Suzie H. Pun
Robert F. Rushmer Professor
Office: Foege N530P
We are developing new materials to improve and/or enable delivery of macromolecule drugs.
The overarching goal of our research is to develop bio-inspired materials for medical applications. Our general approach is to mimic pathways used by nature in our materials design. To this end, we have identified bioactive peptide motifs through both rational design and library selection. In addition, we have developed a method for synthesizing chimeric, peptide-based polymers. Using this approach, we can engineer highly uniform and scalable materials with controlled compositions, structures and sizes that can be used for versatile biomedical applications. The Pun group focuses on door-opening technologies in drug delivery, including innovations for macromolecule delivery to the central nervous system, development of injectable hemostatic polymers, and materials for controlled modulation of the immune system for cancer treatment.
PhD Chemical Engineering California Institute of Technology, 2000
MS Chemical Engineering, California Institute of Technology
BS Chemical Engineering, Stanford University
2015 American Institute for Medical and Biological Engineering (AIMBE) College of Fellows
2014 Controlled Release Society Young Investigator Award
2014 Inaugural Biomaterials Science Lectureship
2008 Undergraduate Mentor Award, University of Washington
2008 Junior Faculty Innovator Award, UW College of Engineering
2007 Outstanding Teacher/Mentor Award, UW Bioengineering
2006 Presidential Early Career Award for Scientists and Engineers (PECASE)
2005 National Science Foundation CAREER Award
2005 Alliance for Cancer Gene Therapy Young Investigator Award
2002 MIT Technology Review’s TR100 Award: “top 100 young innovators”
2000 Everhart Lectureship Prize, California Institute of Technology
Bioen 345: Failure Analysis of Physiologic Systems
Bioen 494/594: Controlled Release Systems
Bioen 498/Bioen 599: Advanced Drug Delivery
Chan, L.W-G., Wang, X., Wei, H., Pozzo, L.D., White, N.J., and Pun, S.H. (2015) Fibrin-crosslinking polymers for modulating clot properties and inducing hemostasis. Sci Trans Med, v7(277):277ra29
Sellers, D.L., Kim, T.H., Mount, C.W., Pun, S.H., and Horner, P.J. (2014) Prolonged hirudin delivery from poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 and functional recovery from a demyelination lesion. Biomaterials, accepted
Cieslewicz, M.E., Tang, J.J., Yu, J., Cao, H., Zavaljevski, M., Lieber, A., Raines, E.W., and Pun, S.H. (2013) Targeted delivery of pro-apoptotic peptides to tumor-associated macrophages improves survival. PNAS, v110:15919-15924.
Wei, H., Volpatti, L.R., Sellers, D.L., Maris, D.O., Andrews, I.W., Hemphill, A.S., Chan, L.W., Chu, D.S.H., Horner, P.J., and Pun, S.H. (2013) Dual-responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angewandte Chemie, v52:5377-5381
Shi, J., Chou, B., Choi, J.L., Johnson, R.N., Schellinger, J.G., and Pun, S.H. (2013) Effect of polyplex morphology on cellular uptake, intracellular trafficking and transgene expression. ACS Nano, v7:10612-10620.
*Wei, H., *Chu, D.S..H., Zhao, J.,Pahang, J., and Pun, S.H. (2013) Synthesis and evaluation of cyclic cationic polymers for gene delivery. ACS Macro Lett, v2:1047-1050.
Chu, D.S.H., Schellinger, J.G., Bocek, M.J., Johnson, R.N., and Pun, S.H. (2013) Optimization of Tet1 ligand density in HPMA-co-oligolysine copolymers for targeted neuronal gene delivery. Biomaterials, v34:9632-9637
Chen, C-Y., Kim, T.H., Wu, W-C., Huang, C.M., Wei, H., Mount, C.W., Tian, Y., Jang, S-H., Pun, S.H., and Jen, A.K-Y. pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. (2013) Biomaterials, v34:4501-4509.
Schellinger, J.G., Pahang, J.A., Johnson, R.N., Chu, D.S.H., Sellers, D.L., Maris, D.O., Convertine, A.J., Stayton, P.S., Horner, P.J., and Pun, S.H. (2013) Melittin-grafted HPMA-Oligolysine Based Copolymers for Improved Gene Delivery. Biomaterials, v34:2318-2326.
Chan, L.W., Wang, Y-N., Lin, L.Y., Upton, M.P., Hwang, J.H., and Pun, S.H. (2013) Synthesis and characterization of anti-EGFR fluorescent nanoparticles for optical molecular imaging. Bioconj Chem, v24:167-175.
Wei, H., Schellinger, J.G., Chu, D.S.H., and Pun, S.H. (2012) Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. JACS, v134:16554-16557.