Office: Foege N430J
Innovative measurement techniques
Another area of focus is in the design of fiber-based scaffolds for biomaterial applications. We have created a custom apparatus that allows the manufacture of well-controlled small diameter fibro-porous meshes. In vivo implant studies have shown that fibers below a certain threshold diameter do not become encapsulated. Current efforts are directed towards better understand on a cell biology level why these fibers are not rejected by host tissue.
Applied research on skin adaptation to mechanical stress is a third area of focus. This research has strong application in Rehabilitation Medicine where it is of interest to encourage adaptation so as to avoid skin breakdown or ulceration (wheelchair users, prosthesis users, bedridden patients). We are using a custom explant model system to investigate the bioprocess changes that occur in skin as it is adapting to repetitive mechanical load.
A long-standing area of research for our group is external prosthetics for amputees. Currently, we are pursuing the development of a control system strategy to maintain consistent interface stress distributions despite changes in residual limb shape and volume over time.
MS Mechanical Engineering – Northwestern University 1985
BS Mechanical Engineering – Stanford University 1983
Sanders JE, Harrison DS, Allyn KJ, Myers TR, Ciol MA, Tsai EC: How do sock ply changes affect residual limb fluid volume in people with trans-tibial amputation? Journal of Rehabilitation Research and Development, vol. 49(2):241-256, 2012
Sanders JE and Fatone S: Residual limb volume change: Systematic review of measurement and management. Journal of Rehabilitation Research and Development, vol. 48(8): 949-986, 2011
Karchin A, Simonovsky FI, Ratner BD, and Sanders JE: Melt electrospinning of biodegradable polyurethane scaffolds. Acta Biomaterialia, vol. 7(9), pp. 3277-3284, 2011
Sanders JE, Rogers EL, Sorenson EA, Lee GS, and Abrahamson DC: CAD/CAM transtibial prosthetic sockets from central fabrication facilities: How accurate are they? Journal of Rehabilitation Research and Development, vol. 44(3), pp. 395-406, 2007
Zachariah SG, Sorenson E, and Sanders JE: A method for aligning trans-tibial residual limb shapes so as to identify regions of shape change. IEEE Transactions on Neural Systems and Rehabilitation Engineering vol. 13(4), pp. 551-557, 2005