Ruikang (Ricky) Wang

Professor

wangrk@uw.edu
Phone: (206)616-5025
Office: Foege N410E

UW Bioengineering faculty Ruikang Wang

Lab Website

How I am inventing the future of medicine

My laboratory is dedicated to developing novel and clinically useful biomedical imaging techniques for early diagnosis, treatment and management of human diseases.
Research Interests

Biophotonics/Biomedical Optics
Functional optical imaging using coherence gating (OCT) and confocal gating techniques
Photoacoustic imaging
Laser Doppler, speckle and intrinsic optical signal imaging
Optical biopsy and functional imaging in tissue engineering
Light propagation in biological tissue
Research Description

By exploring the properties of light, tissue, and their interactions, the Wang lab invented, discovered or pioneered optical microangiography, full-range complex Fourier domain optical coherence tomography, optical clearing of biological tissue, optical elastography, phase-sensitive optical coherence vibrometry, multifunctional nanoparticle contrast agents and their applications in imaging tissue morphology, tissue blood microcirculation (brain, retina, cochlea, skin, muscle etc), tissue mechanical properties and embryonic heart development.
Education

Ph.D., University of Glasgow, 1995
M.Sc., Tianjin University, 1990
B.Eng., Tianjin University, 1988
Postdoc Information

Awards and Honors

Fellow of Optical Society of America (OSA)
Fellow of International Society of Optics and Photonics (SPIE)
Recipient of Research to Prevent Blindness Innovative Research Award
Recipient of OHSU Technology Innovation Award
Editor of Journal of Biomedical Optics Letters
Associate Editor for Biomedical Optics Express, Quantitative Imaging in Medicine and Surgery
UW Bioengineering Courses Taught

BIOEN 420: Medical Imaging
BIOEN 599: Biomedical Imaging
BIOEN 498/599: Optical coherence tomography
Selected Publications

L. An, J. Chao, M. Johnstone, and R.K. Wang, “Non-invasive imaging of pulsatile movements of the optic nerve head in normal human subjects using phase-sensitive spectral domain OCT”, Optics Letters, Vol.38(9), 1512-14 (2013).

Y. Jung, S. Dziennis, Z. Zhi, R. Reif and R.K. Wang, “Tracking dynamic microvascular changes during healing after complete biopsy punch on the mouse pinna using optical microangiography”, PLoS One 8(2): e57976 (2013). doi:10.1371/journal.pone.0057976 .

P. Li, L. An, G. Lan, M. Johnstone, D. Malchow and R.K. Wang. “Extended imaging depth to 12mm for 1050-nm spectral domain OCT for imaging whole anterior segment of human eye at 120 kHz A-scan rate”, Journal of Biomedical Optics 18(1), 016012 (January 2013)

L. An, P. Li, G. Lan, D. Malchow and R.K. Wang, “High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1mm imaging depth”, Biomedical Optics Express 4(2), 245-259 (2013).

P. Li and R.K. Wang. “Optical coherence tomography provides an ability to assess mechanical property of cardiac wall of developing outflow tract in embryonic heart in vivo”, Journal of Biomedical Optics Vol. 17(12), 120502-1 (2012).

R. Reif*, J. Qin*, L. Shi*, S. Dziennis, Z. Zhi, A. Nuttall and R.K. Wang, “Monitoring hypoxia induced changes in cochlear blood flow and haemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system”, PLoS One 7(12): e52041 (2012). doi:10.1371/ journal.pone.0052041 [* equal authors].

Z. Zhi, X. Yin, S. Dziennis, T. Wietecha, K.L. Hudkins, C.E. Alpers, R.K. Wang. “Optical microangiography of retina and choroid and measurement of total retinal blood flow in mice.” Biomedical Optics Express, 3 (11), 2976-2986 (2012)

G. Liu, Z. Zhi, and R.K. Wang, “Digital Focusing of OCT Images Based on Scalar Diffraction Theory and Information Entropy”, Biomedical Optics Express 3(11), 2774 – 2783 (2012)

L. An, M. Johnstone and R.K Wang, “Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects”, Journal of Biomedical Optics 17 (11), 116018 (2012); doi: 10.1117/1.JBO.17.11.116018

S. Dziennis, R. Reif, Z. Zhi, A.L. Nuttall and R.K. Wang, “Effects of hypoxia on cochlear blood flow in mice”, Journal of Biomedical Optics, 17(10), 106003 (2012). DOI: 10.1117/1.JBO.17.10.106003

P. Li, X. Yin, L. Shi, S. Rugonyi, and R.K. Wang. “In vivo functional imaging of blood flow and wall strain in outflow tract of embryonic chick heart using ultrafast spectral domain optical coherence tomography”, Journal of Biomedical Optics, 17 (9), 096006 (2012).

J. Qin, L. Shi, S. Dziennis, R. Reif, and R.K. Wang, “Fast synchronized dual-wavelength laser speckle imaging system for monitoring hemodynamic changes in a stroke mouse model”, Optics Letters, 37 (19), 4005 – 4007 (2012)

R. Reif and R.K. Wang, “Label-free imaging blood vessel morphology with capillary resolution using optical microangiography”, Quant Imaging Med Surg 2(3): 207-212 (2012). DOI: 10.3978/j.issn.2223-4292.2012.08.01

X. Yin, A.P. Liu, Z.H. Ma, K.L. Thornburg, R.K. Wang, S. Rugonyi, “Extracting Heart Outflow Tract of Chicken Embryo from Optical Coherence Tomography 4D Data Using Double-line Model”, Journal of Biomedical Optics 17 (9), 096005 (2012).

Z. Zhi, W.O. Cepurna, E.C. Johnson, J.C. Morrison, R.K. Wang. “Impact of Intraocular Pressure on Changes of Blood Flow in the Retina, Choroid and Optic Nerve Head in Rats Investigated by Optical Microangiography”, Biomedical Optics Express, 3 (9), 2220-2233 (2012).

P. Li, R. Reif, Z. Zhi, E. Martin, T. T. Shen, M. Johnstone, and R.K. Wang, “Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes”, Journal of Biomedical Optics 17 (7), 076026 (2012).

A Liu, X. Yin, L. Shi, P. Li, K. Thornburg, R.K. Wang, S. Rugonyi, “Biomechanics of the chick embryonic heart outflow tract at HH18 using 4D optical coherence tomography imaging and computational modelling”, PLoS ONE 7 (7), e40869, (2012)

H.M. Subhash, A. Nguyen-Huynh, R.K. Wang, S.L. Jacques, N. Choudhury and A.L. Nuttall. “Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry”, Journal of Biomedical Optics 17, 060505 (2012)

P.Y. Leung, S. Hurst, M.A. Berny-Lang, N.G. Verbout, D. Gailani, E.I. Tucker, R.K. Wang, O.J.T. McCarty, A. Gruber, “Inhibition of factor XII-mediated activation of factor XI provides protection against experimental acute ischemic stroke in mice”, Translational Stroke Research, 3 (3), pp 381-389. DOI: 10.1007/s12975-012-0186-5

C. Li, G. Guan, Z. Huang, M. Johnstone, and R.K. Wang. “Non-contact all-optical measurement of corneal elasticity”, Optics Letters 37, 1625-1627 (2012)

R. Reif, J. Qin, L. An, Z. Zhi, S. Dziennis and R.K. Wang. “Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system”, International Journal of Biomedical Imaging, volume 2012 Article ID 509783, 11 pages, (2012). doi:10.1155/2012/509783

X. Zhang, S. Yousefi, L. An, R.K. Wang. “Automated Segmentation of Intra-macular Layers in FD-OCT Structural images from Normal Subjects”, Journal Biomedical Optics 17, 046011 (2012), DOI:10.1117/1.JBO.17.4.046011

C. Li, G. Guan, S. Li, Z. Huang, and R. K. Wang. “Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography”, Journal of Biomedical Optics, 17, 057002 (May 03, 2012); http://dx.doi.org/10.1117/1.JBO.17.5.057002

C. Li, S. Li, G. Guan, C. Wei, Z. Huang, and R.K. Wang, “A comparison of laser ultrasound measurements and finite element simulations for evaluating the elastic properties of tissue mimicking phantoms”, Optics & Laser Technology, 44, 866-871 (2012)

Z. Tan, Y. Liao, Y. Wu, Z. Tang, and R.K. Wang. “Photoacoustic microscopy achieved by microcavity synchronous parallel acquisition technique”, Optics Express, 20 (5), 5802-5808 (2012).

Z. Zhi, Y. Jung and R. K. Wang. “Label-free 3D imaging of microstructure, blood and lymphatic vessels within tissue beds in vivo”, Optics Letters, 37 (5), 812-814 (2012)

J. Qin*, R. Reif*, Z. Zhi, S. Dziennis, and R.K. Wang. “Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system”, Biomedical Optics Express 3 (3), 455-466 (2012) [* = equal authors]

C. Li, G. Guan, X. Cheng, Z. Huang, R. K. Wang, “Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography”, Optics Letters, Vol.37 (4), 722-724 (2012)

Y.R. Jung, G.Y. Guan, C.W. Wei, X. Gao, M. O’Donnell and R.K. Wang, “Multifunctional nanoprobes engineered for enhancing utilities of optical based imaging techniques” Journal of Biomedical Optics 17 (1), 016015 (2012)

D.J. Zha, F.Y. Chen, S. Ramamoorthy, A. Fridberger, N. Choudhury, S.L. Jacques, R.K. Wang, A.L. Nuttall. “In vivo outer hair cell length changes expose the active process in the Cochlea”, PLoS One 7(4): e32757 (2012). doi:10.1371/journal.pone.0032757

C.H. Li, G. Guan, R. Reif, Z. Huang, and R.K. Wang, “Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography”, Journal of the Royal Society Interface, 9 (5) 831-841 (2012). doi: 10.1098/rsif.2011.0583.

 

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