Course: BIOEN 420: Medical Imaging
Instructor: Ruikang (Ricky) Wang, Chun Yuan
Location and Time: HSE E216 Wednesday and Friday 2:30 – 4:00 pm
UW Catalog Description: Various medical imaging modalities (x-rays, CT, MRI, ultrasound, PET, SPECT, optical imaging, etc.) and their applications in medicine and biology. Extends basic concepts of signal processing to the two and three dimensions relevant to imaging physics, image reconstruction, image processing, and visualization.
Prerequisites: Advanced Calculus, Signal and Systems Processing
BIOEN 316 or E E 235; MATH 136, MATH 308, or AMATH 352; CSE 142 or AMATH 301.
Detailed Course Description: This course introduces imaging methods in medicine and biology. Medical imaging systems to be analyzed include conventional X-ray, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine (PET and SPECT), ultrasound and optical imaging. Each of these modalities will be introduced from basic physical principles to the process of image formation. Also, basic concepts in medical image processing and analysis will be introduced. The course includes three hours of lecture per week and four laboratories that will involve actual medical imaging devices. A course project will also be assigned so that students will not only design new medical imaging systems with the knowledge learn in the classroom, but also explore real world applications with reasonable amount self-learning.
Texts and Supplemental Materials:
- Introduction to Biomedical Imaging, Andrew Webb – John Wiley & Sons, Inc, 2003 (required)
Optional Reference Texts:
- Lihong Wang & Hsin-I Wu, Biomedical Optics: Principles and Imaging. John Wiley & Sons, Inc. ISBN: 978-0-471-74304-0 (2007)
- Medical Imaging Physics – Fourth Edition, W.R. Hendee, E. R. Ritenour. Wiley-Liss Inc. 2002.
- Fundamentals of medical imaging, Paul Suetens, Cambridge University Press, 2002.
- The Physics of Diagnostic Imaging D.J. Dowsett, PA Kenny and R.E. Johnston. Chapman & Hall Medical, 1998.
- L. V. Wang and H.-i Wu, Biomedical Optics: Principles and Imaging (Wiley, 2007).
Course Structure: The course employs lectures, 5 laboratories, 4 homework, 2 examinations and a term project.
- CT lab: Students will tour a clinical CT facility.
- Nuclear medicine lab: Students will visit nuclear medicine clinics and hardware lab for PET and SPECT imaging.
- Ultrasound lab: Students will witness and experiment ultrasound image acquisition.
- MRI lab: Students will witness MRI image acquisition and all the noise associated.
- Optical imaging lab: Students will tour optical imaging lab at BioE and witness optical coherence tomography imaging of human eye
- Basic image math/ radiation physics/ nuclear medicine/CT problems
- Ultrasound problems
- MRI problems
- Optical imaging problems
Examinations: There are mid-term and final exams based on lecture concepts. They will be closed book/notes and require a calculator; however one hand-written 8.5×11 inch personal note sheet may be used.
Term Project: The term project is a team effort, and groups will consist of three or four students. The term project requires the teams to either 1) identify, formulate, and solve a specific problem in medical image processing, or 2) use a nuanced and integrated understanding of biology, physiology, advanced mathematics and engineering to explore new applications of medical imaging to a specific organ centered disease. Groups will be required to write a thorough written report and give a 10-minute summary (with a 10-minute Q & A section where questions may be directed at any member of the team) of their term projects to the class.
If the first project is chosen, the group should review an existing algorithm for medical image processing, demonstrate its use, and suggest possible avenues for improving it. If the second project is chosen, the student should review what information can be obtained from each imaging technique for a specific organ/disease, identify the latest research thrusts within that area, and recommend improvements for imaging applications for a patient with the specified disease.
Project Timeline: There are 5 parts of the project that are expected to be submitted by certain due dates
- Team Formation: Students may choose their groups.
- Project Topic: This will be a broad and general topic that your team would like to explore.
- Project Presentation: Your team will have approximately 10 minutes to discuss your project including background, current methods, your improvement (project idea), and advantages and disadvantages of your method. This will then be followed by a 10 min question and answer session. Each team member is expected to ask and answer questions! (45% of project grade)
- Project Report: Your team will try to convince us that your idea has merit. We expect a thorough background of the topic of interest, a discussion of the current methods used along any limitations, what your improvement is and why you think it’s an improvement, and what are the advantages and disadvantages of your team’s idea. There is no minimum requirement or limitation on the report. We expect quality writing as well as an exceptional explanation and idea. (45% of grade)
Computer Resources: The BIOE student laboratory has PC workstations with relevant image processing and statistical software such as Matlab, Mathcad, Splus, SAS etc. The students use the computers to develop and validate their algorithms.
|Lecture 1 – Introduction||CY/RW||Sept 24|
|Lecture 2– X-ray/radiation||CY||Sept 26|
|Lecture 3 – x-ray||CY||Oct 1|
|Lecture 4– CT||CY||Oct 3|
|Lecture 5– Nuclear medicine||CY||Oct 8|
|CT lab||CY||Oct 9|
|Lecture 6– PET/SPECT||CY||Oct 10|
|Nuclear Medicine lab||Oct 14|
|Lecture 7– Optical imaging||RW||Oct 15|
|Lecture 8– optical imaging||RW||Oct 17|
|Lecture 9– optical imaging||RW||Oct 22|
|Optical imaging lab||RW||Oct 22|
|Lecture 10 – image quality/ROC||CY||Oct 24|
|Lecture 11 – mid-term||Oct 29|
|Lecture 12– US||RW||Oct 31|
|Lecture 13 – US||RW||Nov 5|
|Lecture 14 US||RW||Nov 7|
|US lab||RW||Nov 7|
|Lecture 15– mri||CY||Nov 12|
|Lecture 16– mri
|Lecture 17– clinical application of imaging||JM||Nov 19|
|Lecture 18 – mri||CY||Nov 21|
|MRI lab||CY||Nov 25|
|Lecture 19 – MRI||CY||Nov 26|
|Project 1||Both||Dec 3|
|Project 2||Both||Dec 5|
|Final Exam||Dec 9|