Course Title: Bioen 490, Engineering Materials for Biomedical Applications

Instructor: James D. Bryers

Number of credits: 3

 UW General Catalog Course Description:

Combined application of principles of physical chemistry and biochemistry, materials engineering, to biomedical problems and products.  Applications include implants and medical devices, drug delivery systems, cell culture processes, diagnostics, and bioseparations.  Offered: jointly with CHEM E 490 A.

Prerequisites by Course Number: Bioen 326

Prerequisites by topic: Suggested Background by Topics: Cell biology, organic chemistry, physical chemistry, biochemistry.

Instructor’s Detailed Course Description: This course will provide an overview of the field of biomaterials.  The student will learn the history and design principles behind the classes of biomaterials used today in medical devices used as implants in the body or in contact with bodily fluids.  Ultimately, the student will obtain the tools necessary to design, analyze, and characterize biomaterials for new applications.  The course focuses mainly on the materials in actual clinical usage as part of biomedical devices. The major classes of materials along with their properties, characterization, biological responses, and specific clinical applications are presented.  Articles from the current literature are used to highlight ongoing research and development efforts to improve biomaterials and devices.  Students will make presentations on biomaterials used in a specific clinically used device, present an analysis of failure mechanisms of the device, especially failures related to the biomaterials used.  In their term paper, students will propose solutions to be used in the device to overcome one or more of the failure mechanisms of the current version of the device.

Required Textbook: Biomaterials Science, 3rd Edition (2012).  Edited by B. D. Ratner, A. S. Hoffman, F. Schoen, and J. Lemons.  ISBN 9780123746269.

Course Objectives:  The objectives of the course are to provide the students with:

1. Knowledge of chemical and mechanical properties of materials currently used in devices used in contact with the body, their large impact on human health, and the major bodily reactions to the devices (ABET outcomes: h, j, l) – Assessed by: exams.

2. The ability to apply principles in mathematics, science and engineering to the design and evaluation of biomaterials and biomedical devices (c, m) – Assessed by: failure mechanisms presentation, term paper, and exams.

3. An overview of current limitations of biomedical devices and strategies being studied in both academia and industry to address these limitations (h, j) – Assessed by: exams, presentation on biomaterials in current devices, term paper.

4. The opportunity to present their findings of biomaterials used in current devices and their analysis of design limitations of current devices in two oral presentations to their peers and to write a proposal to overcome one or more design limitations of current devices in a written document (g) – Assessed by: biomaterials in current devices and failure of device presentation, term paper.

Class Schedule: Lectures 1 hr. 20 min meet twice a week. Fall 2014 lecture schedule is posted on the course web page.

Computer Use: Students will use computers to prepare their homework, final papers and class presentations.

Laboratory Projects: No labs.

Outcomes Addressed By This Course:

Specific ABET outcomes for Bioen. 490 and their assessment mechanisms are as follows:

(c) An ability to design a system, component, or process to meet desired needs.  Students’ ability will be assessed by their term paper project, in which they will design a novel biomaterial to overcome a known failure mechanism of a currently used device.

(g) An ability to communicate effectively.  Communication will be assessed by one or more of the following: written reading reports on assigned reading, oral presentations of biomaterials used in devices and failure mechanisms of devices, and the written term papers.

(j) Knowledge of contemporary issues.   Students will be evaluated on their understanding of economic and societal forces driving biomaterial and biomedical device development through one or both of the following: written or oral reports on failures of devices, and in the background section of the term paper.  Students will also be evaluated on their knowledge of current state-of-the-art approaches to improved biomaterials and devices through exams and the term paper.

(m) The capability to apply advanced mathematics, science, and engineering to solve the problems at the interface of engineering and biology.  Students will be evaluated on their ability to apply advanced science and engineering through the term paper.

Relationship of Course to Departmental Objectives: Note that these Program Educational Objectives are those approved by the Bioen. faculty on Sept. 14, 2012).

The relationship of Bioen. 490 to department objectives is as follows:

Pursue educational opportunities and/or employment in bioengineering-related fields, such as medicine, device development, or biotechnology.

Earn advanced degrees and/or obtain employment in Bioengineering related fields such as medicine, device development, or biotechnology.

Pursue opportunities for professional growth and development.

Advance their careers by obtaining appropriate educational and professional qualifications.

Serve their profession and community

The wide awareness of the impact of biomaterials on human health care developed in the course prepares the students to serve their profession and community by contributing to their background knowledge of the biomaterials field which will help them become educated reviewers of papers, grant applications, conference abstracts, etc., thereby serving the professional community.

Contribute to responsible development of new technical knowledge.

Bioen. 490 presents the fundamental chemical, mechanical, and biological principles applicable to the biomaterials in currently used devices, including polymer and surface science, biomaterials in drug delivery, biomaterials for tissue engineering, and the biological reactions to implants. The course increases their ability to solve biomedical problems because they have to apply this new knowledge in their term paper to design improved biomaterials and devices.

Course grading:

Item Course Points
Homework (5 assignments) 50 points
2 Exams 100 points
Total Course Points 250

Your grade will be set by the fraction of the 250 course points you obtain.

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