Dr Bermingham-McDonogh received an Institute for Stem Cell and Regenerative Medicine Innovation Pilot Award for her grant entitled "Determining the pattern of gene expression in support cells that defines support cell competence to generate hair cells in the mouse crista."
A new NIH grant has been awarded to Dr. Zipora Yablonka-Reuveni. The project is driven by her lab's novel discovery of a secondary myogenic lineage in extraocular muscles (EOMs) that specifies the EOM orbital layer and may contribute to the unique sparing of this muscle group in Duchenne muscular dystrophy and in dystrophin-null animal models. The immediate aim is to establish and evaluate several Cre/loxP mouse models for the impact on the emergence of the EOM secondary myogenic lineage. The results could contribute to breakthrough findings toward refining our understanding of mechanisms involved in eye muscle functional specification and the sparing of the EOMs in muscular dystrophy.
This R01 supports the development of a unified model of visual motion and binocular integration in the cerebral cortex. It is specifically aimed at explaining the responses of populations of single neurons at multiple stages from area V1 to area MT that are important for understanding our ability to see motion in depth. This is a collaborative grant with two experimental labs: Prof. Adam Kohn (Einstein School of Medicine, Bronx) and Prof. Alex Huk (UT, Austin), who will carry out electrophysiological and psychophysical experiments. The grant arises largely from the circuit modeling work of Dr. Pamela Baker, an Acting Instructor in the Bair lab.