Skeletal muscle stem cells - origin, function & dysfunction in adult life
Our research focuses on the regulation of myogenic stem cell function in adult life. Our long-term goal is to identify means to ameliorate age-related muscle deterioration (sarcopenia) and combat muscle wasting in muscular dystrophy. We investigate satellite cells, classically defined tissue specific myogenic stem cells that reside beneath the myofiber basal lamina, as well as non-myogenic progenitors associated with the microvasculature that may contribute to myogenesis by myogenic reprogramming.
The following research areas are pursued:
Mechanisms involved in supporting myogenic commitment and renewal of satellite cells.
The role of FGF-FGFR system in regulating satellite cells.
The role of Klotho genes in the balance between myogenicity and adiposity of skeletal muscle.
Origin and cellular/molecular distinctions of satellite cells from extraocular muscles (EOM) that contribute to enhanced stem cell performance and sparing from muscular dystrophy.
Origin and significance of unconventional progenitors that may function to replace myonuclei during myofiber maintenance. Emphasis is given to the role of cells associated with the microvasculature, in particular the pericytes.