Research

Dr. Chung is interested in the molecular genetics of factor XI deficiency, the structure and function of fibrinogen, and the regulation of gene expression.

Selected Publications

Chung DW, Fujikawa K (2002) Processing of von Willebrand factor by ADAMTS-13. Biochemistry 41, 11065-70.

Andersen H, Greenberg DL, Fujikawa K, Xu W, Chung DW, Davie EW (1999) Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci USA 96, 11189-93.

Xu W-F, Xie Z-W, Chung DW and Davie EW (1998) A Novel Actin-Binding Protein Homologue that Binds to Platelet Glycoprotein I§alpha. Blood, 92, 1268.

Cote HC, Pratt KP, Davie EW, Chung DW (1997) The polymerization pocket "a" within the carboxyl-terminal region of the gamma chain of human fibrinogen is adjacent to but independent from the calcium-binding site. J Biol Chem 272, 23792.

Pratt KP, Cote HC, Chung DW, Stenkamp RE, Davie EW (1997) The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. Proc Natl Acad Sci 94, 7176.

Xu W, Chung DW, Davie EW (1996) The assembly of human fibrinogen. The role of the amino-terminal and coiled-coil regions of the three chains in the formation of the alphagamma and betagamma heterodimers and alphabetagamma half-molecules. J Biol Chem 271, 27948.

Hu CH, Harris JE, Davie EW, Chung DW (1995) Characterization of the 5'-flanking region of the gene for the alpha chain of human fibrinogen. J Biol Chem 270, 28342.