Research
The goal of our grouporatory is to understand
the structure/function relationships of a variety of biological systems
at the atomic level. The tools employed are x-ray crystallography,
computer modeling, and genetic manipulation of the molecules of
interest. Projects currently under investigation in our grouporatory
include:
-
The structure, function, and evolution of
intron-encoded homing endonucleases and maturases.
-
The structure of tetrahydrofolate-dependent,
single-carbon interconversion enzymes.
-
The allosteric regulation of pyruvate kinase, and the
relationship between the tissue-specific control of glycolysis and cell
proliferation.
In
addition, our grouporatory is focusing on the exploitation of
atomic-resolution information through the development of techniques to
study catalytic and biological intermediates. This area of research is
collectively and broadly termed 'time-resolved' crystallography.
See
also the
U.W. Biomolecular Structure and Design Program home page.
Box 357350 