Newman JC, Weiner AM (2005) L2L: a simple tool for discovering the hidden significance in microarray expression data. Genome Biol 6, R81. | |  |
L2L was featured on the Netwatch page of Science (highlighted above):
TOOLS
Stacking Gene Chips
Microarrays reveal which genes crank up or slow down in diseases such as diabetes and cancer, but they yield a torrent of data that leaves many researchers feeling swamped. A new site called L2L (for "list-to-list") from the University of Washington, Seattle, can help scientists cope with the flood. Users plug in their lists of regulated genes, and L2L compares them to more than 350 other lists compiled from published microarray papers. The output highlights common patterns of gene expression that suggest underlying molecular mechanisms. L2L can help researchers tease apart the effects of complex diseases on gene activity. L2L is available online at http://depts.washington.edu/l2l/. |
Other Breaking News
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Tom Schmidlin is disguised by day as a mild-mannered graduate student working with Assistant Professor of Biochemistry, Brian Kennedy, on the yeast Saccharomyces cerevisiae as a model for human aging, but Schmidlin also has a secret life: He was chosen as “Beerdrinker of the Year”. |
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Using a mouse model, Thomas Hnasko of the Graduate Program in Neurobiology and Behavior and Professor Richard Palmiter have investigated the role of dopamine in the behavioural responses to drugs of abuse. As first author, Hnasko was interviewed by Nature. |
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Regulatory pathway linking nutrition and aging characterized by graduate student Kristan Steffan, Assistant Professor of Biochemistry Brian Kennedy, and Matt Kaeberlein, a postdoctoral fellow with Stan Fields, Professor of Genome Sciences. |
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Specific lipid-protein interactions can be visualized in the structure of two-dimensional Aquaporin-0 crystals as determined by cryoelectron microscopy ("cryo em") at the remarkable resolution of 1.9 Angstroms. Tamir Gonen, now an Assistant Professor of Biochemistry, recently completed this work as a postdoctoral fellow with Professors Thomas Walz and Stephen Harrison at Harvard Medical School. |
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Early detection screens for six metabolic disorders in newborns developed byMichael Gelb, Professor of Chemistry and Adjunct Professor of Biochemistry |
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Nature features work by Biochemistry graduate student Steve Hatfield and Professor Hannele Ruohola-Baker on role of microRNAs in Drosophila stem cell |
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Real estate magnate isolates DNA from strawberry under watchful eye of Biochemistry graduate student Michelle Baranski |
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