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STAFF
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GRADUATE STUDENTS
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NEW STUDENTS
Hannele Ruohola-Baker
Hannele Ruohola-Baker
Professor of Biochemistry
Associate Director, Institute for Stem Cell and Regenerative Medicine (ISCRM)
Adjunct Professor, Department of Biology
Adjunct Professor, Genome Sciences
Ph.: 206.543.8468
 
Fax: 206.543.8468

Research

My laboratory offers very fruitful and multi-disciplinary approaches for understanding the dynamics and differentiation of stem cells. We use multiple in vivo, ex vivo and in vitro models ranging from Drosophila to mouse to hESC and iPSC to understand the regulation of regeneration. In recent years we have shown that microRNAs and HIF pathway play key roles in regulating adult and embryonic stem cells. Through unbiased Drosophila interaction screen we discovered that increasing the sphingosine-1-phosphate pathway (S1P) has therapeutic effects on muscular dystrophies. Increased S1P levels also show a beneficial effect in adult stem cell based muscle regeneration in mdx, the mouse DMD model. These basic studies are directed towards a long-term goal of stem cell and small molecule based therapeutics.

 

DrosophilaEmbryo
NotchTumorSuppressor
Notch as a tumor suppressor

 

Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila
DistroglycanPolarizesOocyte DistroglycanPolarizesOocytes

 

Distroglycan in signalling
DistroglyanRibbonDiagram

 

GermlineMicroRNA

Publications:

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