PEOPLE
FACULTY
FACULTY
STAFF
STAFF
GRADUATE STUDENTS
GRADUATE STUDENTS
Hannele Ruohola-Baker
Hannele Ruohola-Baker
Professor of Biochemistry
Associate Director, Institute for Stem Cell and Regenerative Medicine (ISCRM)
Adjunct Professor, Department of Biology
Adjunct Professor, Genome Sciences
Off.: S581 SLU
 
Ph.: 206.543.8468
 
Fax: 206.543.8468

Research

The Ruohola-Baker laboratory is dissecting the molecular mechanisms that control stem cell self-renewal and regeneration capacity, both in normal and pathological situations. We have identified metabolic differences between pluripotent, pre- and post-implantation ESC and are now dissecting how metabolites regulate epigenetic states. The laboratory works on three questions: 1) metabolic determinants of stem cells and regeneration 2) stem cell aging and 3) using stem cells to dissect the mechanism of disease states. The laboratory is dissecting the etiology of long chain fatty acid induced SIDS, a heart defect that can cause sudden infant death and Amelogenesis Imperfecta (AI), a defects in stem cells for ameloblasts that normally deposit enamel, the hardest tissue in our body.

DrosophilaEmbryo
NotchTumorSuppressor
Notch as a tumor suppressor

 

Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila
DistroglycanPolarizesOocyte DistroglycanPolarizesOocytes

 

Distroglycan in signalling
DistroglyanRibbonDiagram

 

GermlineMicroRNA

Publications:

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