Photograph used with permission of patient
Paget's disease is disorder of bone remodeling which is focal (located in discrete areas in the bones and not throughout the entire skeleton). The abnormal remodeling results in overgrowth or deformity of bone. Paget's disease usually occurs in adults who are older than 55 years old, and there are slightly more men than women with the disease. The disease does not spread, but remains in the same bones as patients grow older. It it most commonly found in the skull, spine, pelvis, femur, and tibia. Whereas some patients have only one bone with Paget's disease, others have Paget's in many bones. The reason for this distribution within the bone remains a mystery.
Paget's disease patients are wonderful people, bright and otherwise healthy, living full lives. Many patients with Paget's disease of bone have no symptoms. This is particularly true if the Paget's disease affects only one bone (monostotic). Other patients have bone pain. In some patients bone pain and crippling deformities of bone occur, requiring treatment with medication and/or surgery.
The joints next to the bones involved with Paget's often develop arthritis. Other complications are the result of bone overgrowth near nerves. For example, if there is Paget's disease in the skull the patient may have problems with hearing. Rare complications include spinal cord paralysis, heart failure, and bone cancer. The blood flow through Pagetic bone is very high, so sometimes the overlying skin is warmer than the skin over non-involved bones.
Since the discovery of new drugs for the treatment of Paget's disease in the last 10 years, patients are being identified and treated earlier. It is hoped that problems from overgrowth of bone will be prevented in this way.
. . . about Paget's disease
|Back to Diseases|