Fred Hutchinson Cancer Research Center
Proteins account for the largest fraction of macromolecules in most living cells. In fast growing cells such as microorganisms and cancer cells, over a third of the nutrients and energy used by the cells goes towards making proteins. Because of this large demand on cellular resources, the rate of protein synthesis is often tightly regulated depending on nutrient levels in a cell’s growth environment. Research in our lab uses genomic and computational approaches with the goal of understanding the molecular mechanisms and cellular design principles underlying the regulation of protein synthesis.