This project deals with the electrical activity of and communication between neurons in the human temporal cortex during language and memory tasks. Extracellular voltage measurements are taken from the temporal cortex in locally anesthetized craniotomy patients. The patient is presented with behavioral paradigms while neuronal activity is recorded. The recordings are then correlated with stimulus presentation. This project offers invaluable experience for students who would like to pursue careers in clinical biomedical research. As well as operating room and clinical exposure, the student will gain experience collecting, digitizing and analyzing neural activity. The student will analyze temporal properties of neuronal response using a variety of digital wave analysis software packages. Advanced data analysis is statistics-intensive and statistical software packages such as SPSS, Systat and Excel will be used to analyze inter-spike interval differences and multineuron spike-triggered averaging.