Research focuses on the association between folic acid intake and homocysteine. This project is best suited for students interested in public health intervention research in a clinical setting. It is excellent experience for a student wanting to pursue a research career with human populations. The project deals with the mechanism and amount by which varying doses of folic acid supplementation reduces plasma homocysteine levels. The student will learn about the pathways involved in folate and homocysteine metabolism, and will assist with all aspects of conducting a clinical trial. Experience will be gained in data collection, data tracking, data cleaning, and data analysis using MSAccess and MSExcel. The student will be able to characterize the segment of the population that might be at risk for insufficient intake of folic acid. The student will also characterize the effect of insufficient intake of folic acid on homocysteine levels, discussing the effect on heart disease risk.