About the Bush Lab

The Bush Lab is a research group in the Department of Chemistry and the Biological Physics, Structure & Design Program at the University of Washington. Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines.

  • Interested in joining the Bush Lab? Click here to learn about current opportunities.
  • Our weekly group meetings are held on Tuesdays at 5:00 PM in CHL 068B.

Recent News

New NIH Award!

The Bush Lab was just awarded a grant from the National Institutes of Health for a project titled “Increasing the Selectivity of Hybrid Mass Spectrometry Using Multidimensional Ion Mobility Spectrometry” (R01 GM130708). We are excited to pursue this research and are grateful for this financial support from the NIH.

Matt Bush appointed as an Affiliate of the UW eScience Institute

The Bush Lab is excited to join the eScience Institute, which empowers researchers and students in all fields to answer fundamental questions through the use of large, complex, and noisy data. As the hub of data-intensive discovery on campus, the eScience Institute leads a community of innovators in the techniques, technologies, and best practices of …


Most proteins, particularly those that accomplish complicated tasks, form assemblies with other proteins and molecules that are critical to their function. Established structural biology tools are most effective for highly purified samples that have limited conformational variability, which makes it challenging to apply those methods to capture a systems-wide understanding of the structures, interactions, and dynamics that are present under different cellular conditions. The Bush Lab develops and applies mass spectrometry based techniques that are fast, sensitive, and tolerant of heterogeneity for characterizing the native structures of biological assemblies.