Matt Bush

Matthew F. Bush
University of Washington | Department of Chemistry | Box 351700 | Seattle, WA 98195-1700 | | ORCID


Matt Bush pursued his Ph.D. from 2003-2008 with Evan Williams and Richard Saykally at the University of California, Berkeley. During that time he used infrared laser spectroscopy and Fourier-transform ion cyclotron resonance mass spectrometry to investigate zwitterion formation in gas-phase biomolecules and the structural effects of hydration on biomolecular and multiply charged ions. This training in high-performance mass spectrometry and physical chemistry laid the ground work for his continued pursuits using gas-phase techniques to investigate the structures and interactions of biomolecules. In 2008 he joined the laboratory of Carol Robinson FRS DBE at the University of Cambridge and the University of Oxford, during which time he was a Waters Research Fellow, a Junior Research Fellow of Jesus College, University of Oxford, and developed experimental and analytical frameworks for using ion mobility mass spectrometry experiments to characterize the structures of drug-like molecules, peptides, proteins, and protein complexes. He joined the chemistry faculty at the University of Washington in 2011, where he is also a member of the Department of Biochemistry, the Biological Physics, Structure and Design Program, and the Molecular Engineering & Sciences Institute. His research group is focused on developing mass spectrometry based approaches for elucidating the structures, assembly, and dynamics of biological molecules. His group applies these approaches to a wide range of biological systems, with a focus on those involved in protein homeostasis.

Current Positions at the University of Washington

Previous Positions & Education


  • Arthur F. Findeis Award for Achievements by a Young Analytical Chemist | 2017
  • Eli Lilly Young Investigator Award in Analytical Chemistry | 2014 | Information
  • Sloan Research Fellow | Alfred P. Sloan Foundation | 2014 | Information
  • Research Award | American Society for Mass Spectrometry | 2013 | Information
  • Junior Research Fellow | Jesus College | University of Oxford | UK | 2010–2011
  • Waters Research Fellow | 2010–2011


Professional Service (selected)

  • Advancing Mass Spectrometry for Structural Biology and Biophysics Conference
    • Board (2015–present)
    • Organizer of AMS 2021
  • American Chemical Society, Division of Analytical Chemistry
    • Long-Range Program Planning Committee, Chair (2017-present)
    • Long-Range Program Planning Committee, Member (2015-present)
  • American Society for Mass Spectrometry
    • Asilomar Committee (2015–2017)
    • Fall Workshop Co-Organizer (2014)
    • Ion Mobility MS Interest Group Coordinator (2012–2014)