EDUCATION AND TRAINING
Cardiology Fellowship, University of Washington (Chief Fellow), Seattle, WA, 1994-1997.
Internship and Residency, University of Virginia (Chief Resident), Charlottesville, VA, 1990-1993.
M.D., University of Connecticut School of Medicine, Farmington, CT, 1990.
B.A., Dartmouth College, Hanover, NH, 1986.
April Stempien-Otero M.D., F.A.C.C.
Associate Professor of Medicine
Craig Tall Family Endowed Professorship
in Heart Failure Research
Attending Physician, University of Washington
UW Research - South Lake Union Complex
850 Republican Street, Brotman 142
Seattle, WA 98109
Fax: (206) 598-4669
American Board of Internal Medicine, 1994, 2007.
American Board of Internal Medicine, Cardiovascular Diseases, 1997, 2007.
AREAS OF CLINICAL EXPERTISE
Congestive heart failure and cardiac transplantation
CURRENT RESEARCH INTERESTS
Role of macrophages in cardiac fibrosis and remodeling
Injection of bone marrow subsets into the heart at LVAD placement to modify human cardiac matrix
Cellular basis of protease-mediated cardiac fibrosis
2002, Mentored Physician Scientist Award, NIH
2002-present, Best Doctors in America
2003-2004, Vice President, Executive Board, American Heart Association, Metro King County
2006, CME Teacher of the Year, University of Washington School of Medicine
1997, ATVB Merit Award, American Heart Association Annual Meeting
1996, Fellowship Award, American Heart Association, Washington Affiliate
Moriwaki, H, Stempien-Otero, A, Kremen, M, Cozen, AE, Dichek, DA, Overexpression of uronkinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice, Circ. Res. 941-8, 2004.
Stempien-Otero A, Plawman A, Meznarich J, Dyamenahalli T, Otsuka G, Dichek DA, Mechanisms of cardiac fibrosis induced by urokinase plasminogen Activator, J. Biol. Chem. 281:15345–15351, 2006.
Kremen M, Krishnan R, Emery I, Hu JH, Slezicki KI, Wu A, Qian K, Du L, Plawman A, Stempien-Otero A, Dichek DA. Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice. Proc. Natl. Acad. Sci. U.S.A. 105:17109-17114, 2008.
Minami E, Castellani C, Malchodi L, Deem J, Bertko K, Meznarich J, Dishmon M, Murry CE, Stempien-Otero A. The role of macrophage-derived urokinase plasminogen activator in myocardial infarct repair Urokinase attenuates ventricular remodeling. J. Mol. Cell. Cardio. Sep;49(3):516-24, 2010.